Entitled "ISOLATION and characterization of H7N9 viruses from live poultry Markets
2013-04-23 02:39
A new study suggest that the recent novel H7N9 influenza virus in our country to cause human infections with the same period exists in the live bird markets on the H7N9 avian influenza virus is highly homologous to provide a basis for further control measures.
- implication of the source of the current H7N9 infection in Humans" research papers will be published in "Science Bulletin" in English.Initially from the etiological point of view, the study reveals the characteristics of the new H7N9 influenza virus, written by the Chinese Academy of Agricultural Sciences, Harbin Veterinary Research Institute researcher Chen Hua-lan and researcher Li Chengjun as Corresponding author.
March 31, 2013, the National Health and Family Planning Commission announced a new type of human infection with the H7N9 influenza virus in Shanghai and Anhui. Harbin Veterinary Research Institute, National Avian Influenza Reference Laboratory to respond quickly to rapidly identify the source of the new H7N9 virus, which is essential to develop scientific and rational prevention and control measures.
Researchers etiological 970 samples were collected in Shanghai, Anhui, live poultry markets and farms have been tested, of which 20 H7N9 avian influenza virus positive. Gene sequence analysis showed that the H7N9 avian influenza virus gene fragments are highly homologous with the H7N9 human isolates proved to cause human infections and lethal H7N9 influenza virus directly from the same period in poultry popular H7N9 avian influenza virus.
The researchers said, it should be noted that these viruses isolated from the live bird markets samples collected samples of all farms were negative, suggesting that our new H7N9 virus may initially be generated in the live poultry market. The new H7N9 influenza virus is a the different sources virus recombinant virus and six internal genes from the H9N2 avian influenza virus, HA and NA genes is unclear sources.
The researchers found that the novel H7N9 virus receptor binding sites a part of the human influenza virus definitions mutation, in addition to the virus after infection by adaptive mutation of the critical amino acid positions, these may also infection with the virus, and lethal ability.
The recommendation of the National Avian Influenza Reference Laboratory, Ministry of Agriculture and the Shanghai municipal government shut down the live bird markets in Shanghai, in order to cut off the source of the spread of the virus. National Avian Influenza Reference Laboratory to act quickly, in order to effectively control the new H7N9 avian influenza virus, H7N9 avian influenza virus by RT-PCR diagnostic kit to the national veterinary disease control department, and provides a standard diagnostic antigen and serum. Reference Laboratory reserves H7 subtypes of avian influenza virus vaccine, the immune protective effect of the vaccine against the new H7N9 avian influenza virus is in the process of making an assessment of the process, and the Reference Laboratory researchers are working intensively to develop specifically for the new H7N9 avian influenza virus vaccines, and strive to put into use as soon as possible.
National Avian Influenza Reference Laboratory director Chen Hua-lan researcher believes that the greater threat to human health in order to control the H7N9 avian influenza virus, on the basis of the preliminary work more vigorously to strengthen the detection of the H7N9 avian influenza virus in poultry, to identify the virus source and route of transmission, and carry out the H7N9 virus pathogenicity, the ability to communicate and pathogenesis in animal models.
It is understood that the study was funded by the National Key Basic Research and Development Program, the the national broiler industry technology system project and the national science and technology major special projects.http://www.kaixian.tv/R1/n2015297c19.shtml
