Led by mainland Chinese Academy of Engineering Li Lanjuan dry ports scientists, published online in the internationally renowned medical journal "The Lancet", alleging that the H7N9 virus gene like a spiral staircase, which has four steps and positioning is the key, if they suddenly change human-to-human transmission will become fact. The study found that three steps has changed. She warned, "four steps once the shift will be human-to-human transmission!"
This by Li Lanjuan led, between Hong Kong and clinical experts together to complete the research paper, the problem of the H7N9 virus genes, the source of infection of the disease, and the spread of the virus, etc., with the new interpretation.
Virus genes and loci 3/4 Shift
The Li Lanjuan H7N9 has its unique gene sequences of the virus gene sequences compared to a long staircase, then different genes and loci, as if one of the steps and positioning.
The study found that H7 genes of the two amino acid sites "shift", the equivalent of two steps location changed, which means that the affinity of the virus and human airway epithelial cells enhanced, so in the spring of this year, H7N9 is easily which passed from birds to people.
But whether from person to person, the key to look at another PB2 gene, this gene also has two amino acid sites. The research team found that one of the sites of variation to be highly vigilant If these two amino acid sites mutated virus will effective human-to-human transmission occurs.
The Li Lanjuan said and the conventional H5N1 and other influenza A type virus, this locus had happened variation. However, it is not equal to H7N9 after saying it will not change, "I hope the terrible results of the first four steps of shift does not occur! We will pay close attention to early warning as possible."
The viral tropism lung artificial liver technology can inhibit
The clinical study also found that symptoms of the H7N9 avian influenza infection with the H5N1 avian influenza were similar, patients with high fever and breathing difficulties and other symptoms, the next 3 to 14 days of respiratory failure. In other words, the H7N9 virus is indeed "L. pneumophila".
Researchers in the clinical treatment, creative application of artificial liver technology, to clear inflammatory factors, inhibiting the inflammatory response, to help patients through the difficulties of organ failure, thereby reducing the mortality rate.http://news.chinatimes.com/focus/11050105/112013042800068.html
The academicians denied the H7N9 virus gene shift a great human-to-human transmission "
....Yesterday, media reports said, the Chinese Academy of Engineering the national guard Planning Commission infectious disease focus research director Li Lanjuan, team New research shows that people infected with the H7N9 virus source of infection has been recognized as chicken and other poultry, and worries people most concerned about the people descendant of the suspense has also been emerging: the virus genes, such as a spiral staircase, has found three "steps" position has changed, if there is a "step" shift would undermine the stability of the stairs, then the virus will lead to "human-to-human transmission.
Since then, the Academy of Sciences said the H7N9 virus gene 3 shift, then shift to a human-to-human transmission of the message spread rapidly.
Yesterday, Li Lanjuan, an interview with CCTV said two gene mutation will occur at the same time more effective communication which infection is only for poultry-to-human transmission, she categorically denied said "human-to-human transmission. As for human-to-human transmission of the virus does not occur, can not certainly can not deny the need for further research and monitoring...
...The study found that four "steps" and positioning is the key. Study found that a H7 gene in the two amino acid sites has occurred "shift", the equivalent of two steps location changed, which means that the affinity of the virus and human respiratory epithelial cells is enhanced, so this spring, H7N9 passed from birds to people a breeze.
At present, the research team has found them a bit mutate to be highly vigilant, if these two amino acid sites mutate at the same time, will enable the virus to spread... http://news.cntv.cn/2013/04/28/ARTI1367104064501780.shtml
