Health: the death of Saudi woman Corona virus ??

Health: the death of Saudi Corona virus new style

Did not respond to the treatment ..

    Ministry of Health announced the death of a Saudi woman proved results of laboratory tests diagnosed to be infected with HIV Coruna new style (Severe Acute Respiratory Syndrome).

The citizenship have entered a hospital in the city of Riyadh after returning from a trip outside the Kingdom, where diagnosed with bird flu symptoms, acute respiratory and gave her appropriate supportive therapy like viruses that cause respiratory infections such as seasonal flu but she did not respond to treatment.

The ministry has shown that it continues to follow the developments in the situation about this new virus in coordination with international organizations and international medical bodies and regional markets where it has taken preventive measures and epidemiological investigation of Mkhaltin and hospital staff.

Also been informed stakeholders including the World Health Organization by the International Health Regulations (IHR), and it should be noted that this case of death (13) at the level of the world because of this virus.  http://www.alriyadh.com/net/article/812366

Early quarantine best way to avert Sars-like outbreak: health chief

Swift isolation of suspected cases is at the core of the government's strategy to prevent another epidemic, the health minister says

It was a dreaded scene from years ago: people clad in full protective gear entering and exiting a quarantined hotel in a city caught in the grip of a fatal virus.

That scene, which emerged in 2003 and then again in 2009, may return to haunt Hong kongers if another epidemic strikes.

Ten years from the dark days of the 2003 Sars crisis, the health chief who battled the severe acute respiratory syndrome virus says the government still considers an early quarantine strategy the best way to avert an outbreak.

Food and Health Bureau Secretary Dr Ko Wing-man was responding to concern that a new Sars-like coronavirus had surfaced in the Middle East and that the city's overloaded public hospitals lacked the capacity to deal with another such crisis.

"This is a lesson we learned from Sars," said Ko, who was at the forefront of the battle as the Hospital Authority's acting chief executive at the time. "We must cut off the transmission chain at a very key moment to stop suspected cases from spreading."

The government might use hotels or holiday campsites to isolate people should the need arise to undertake a large-scale quarantine at the community level, he said. When Sars took hold of the city, an entire block at Amoy Gardens, the Kowloon Bay estate where 42 victims eventually died, was isolated. About 240 residents were taken to quarantine camps.

The most recent memory of the practice was in 2009, when nearly 300 employees and guests at the Metropark hotel in Wan Chai were quarantined for seven nights after a Mexican guest was found infected with swine flu. All were released in good health.

Back then, the government faced criticism that it had overreacted. "But the [quarantine] policy is necessary … We have to put emergency measures in place at a very early stage, even if it comes before the scientific evidence," Ko said. "Still, it is always hard to decide who and when to isolate."

Ko said the city had not seen any serious suspected or confirmed case of the new virus, but now the government was better prepared. "Our stored emergency resources … can be used for a month," he said.

Doctors would isolate and run tests on patients displaying Sars-like symptoms, he said. Public hospitals have increased their number of isolation beds to 1,400. Five hundred of those beds can be used immediately, with the rest ready for use within 72 hours.

Ko said the isolation wards should be reserved for infected cases who showed serious symptoms and needed treatment. Their close contacts would be quarantined in the community.

"[The hospitals' overall lack of capacity] is a problem we are facing as we cope with huge local and overseas demand," Ko admitted. "The government has to work hard to expand the service in the public and private sectors."

In 2003, Ko took over from Hospital Authority chief William Ho Shiu-wei after Ho contracted Sars. Ko resigned in 2004.

 http://www.scmp.com/news/hong-kong/article/1156406/early-quarantine-best-way-avert-sars-outbreak-health-chief

Efficient Replication of the Novel Human Betacoronavirus EMC on Primary Human Epithelium Highlights Its Zoonotic Potential

1. Eveline Kindler^a, 
2. Hulda R. Jónsdóttir^a, 
3. Doreen Muth^b, 
4. Ole J. Hamming^c,
5. Rune Hartmann^c, 
6. Regulo Rodriguez^d, 
7. Robert Geffers^e,
8. Ron A. M. Fouchier^f, 
9. Christian Drosten^b, 
10. Marcel A. Müller^b,
11. Ronald Dijkman^a, 
12. Volker Thiel^a,g

+Author Affiliations

1. Institute of Immunobiology, Kantonal Hospital, St. Gallen, Switzerland^a;
2. Institute of Virology, University of Bonn Medical Center, Bonn, Germany^b;
3. Department of Molecular Biology and Genetics, Centre for Structural Biology, University of Aarhus, Aarhus, Denmark^c;
4. Institute of Pathology, Kantonal Hospital, St. Gallen, Switzerland^d;
5. Genome Analytics Group, Helmholtz Center for Infection Research, Braunschweig, Germany^e;
6. Viroscience Lab, Erasmus Medical Center, Rotterdam, The Netherlands^f;
7. Vetsuisse Faculty, University of Zürich, Zürich, Switzerland^g

1. Address correspondence to Ronald Dijkman, Ronald.Dijkman@kssg.ch, or Volker Thiel, Volker.Thiel@kssg.ch.

1. Editor Michael Buchmeier, University of California, Irvine

ABSTRACT

The recent emergence of a novel human coronavirus (HCoV-EMC) in the Middle East raised considerable concerns, as it is associated with severe acute pneumonia, renal failure, and fatal outcome and thus resembles the clinical presentation of severe acute respiratory syndrome (SARS) observed in 2002 and 2003. Like SARS-CoV, HCoV-EMC is of zoonotic origin and closely related to bat coronaviruses. The human airway epithelium (HAE) represents the entry point and primary target tissue for respiratory viruses and is highly relevant for assessing the zoonotic potential of emerging respiratory viruses, such as HCoV-EMC. Here, we show that pseudostratified HAE cultures derived from different donors are highly permissive to HCoV-EMC infection, and by using reverse transcription (RT)-PCR and RNAseq data, we experimentally determined the identity of seven HCoV-EMC subgenomic mRNAs. Although the HAE cells were readily responsive to type I and type III interferon (IFN), we observed neither a pronounced inflammatory cytokine nor any detectable IFN responses following HCoV-EMC, SARS-CoV, or HCoV-229E infection, suggesting that innate immune evasion mechanisms and putative IFN antagonists of HCoV-EMC are operational in the new host. Importantly, however, we demonstrate that both type I and type III IFN can efficiently reduce HCoV-EMC replication in HAE cultures, providing a possible treatment option in cases of suspected HCoV-EMC infection.

IMPORTANCE A novel human coronavirus, HCoV-EMC, has recently been described to be associated with severe respiratory tract infection and fatalities, similar to severe acute respiratory syndrome (SARS) observed during the 2002-2003 epidemic. Closely related coronaviruses replicate in bats, suggesting that, like SARS-CoV, HCoV-EMC is of zoonotic origin. Since the animal reservoir and circumstances of zoonotic transmission are yet elusive, it is critically important to assess potential species barriers of HCoV-EMC infection. An important first barrier against invading respiratory pathogens is the epithelium, representing the entry point and primary target tissue of respiratory viruses. We show that human bronchial epithelia are highly susceptible to HCoV-EMC infection. Furthermore, HCoV-EMC, like other coronaviruses, evades innate immune recognition, reflected by the lack of interferon and minimal inflammatory cytokine expression following infection. Importantly, type I and type III interferon treatment can efficiently reduce HCoV-EMC replication in the human airway epithelium, providing a possible avenue for treatment of emerging virus infections.

This Article

1. doi: 10.1128/​mBio.00611-1219 February 2013 mBio vol. 4no. 1 e00611-12

1. All Free via Open Access: OA
3. » Abstract
4. OA Importance
5. OA Figures
6. OA Full Text
7. OA PDF
8. http://mbio.asm.org/content/4/1/e00611-12

New deaths Department of Health to closely monitor overseas novel coronavirus caused severe respiratory disease

February 22, 2013

Department of Health (DH) today (February 22) is closely monitoring the health department reported to the World Health Organization (WHO) by the Kingdom of Saudi Arabia (Saudi) to add a new coronavirus infection deaths.

The patient was admitted to hospital on January 29, subsequently died on February 10. The case on February 18, after laboratory tests confirmed. Saudi health authorities are further investigating the cases.

The number of new cases around the world has confirmed infection novel coronavirus caused severe respiratory disease cases increased to thirteen (including seven deaths), six of which came from Saudi Arabia (including four deaths).

Department of Health spokesman said: "The response to the latest development, the Centre for Health Protection of the Department of Health will be more information to follow up cases to WHO and the health sector. Addition, the CHP will remain vigilant, continue to work with the WHO and overseas health departments work closely monitor the latest development of this new type of infectious disease. "

In addition, Hong Kong has been implemented to strengthen the monitoring of the measures of the new type of coronavirus, from today to further strengthen the monitoring of the laboratory tests of a new type of coronavirus.Required to undergo intensive treatment for unexplained pneumonia cases, cases of pneumonia, pneumonia group cases or cases of health care workers infected with pneumonia, regardless of their travel records, authorities the novel coronavirus constancy laboratory.

The spokesman said: "The CHP will continue with various public and private hospitals, medical practitioners and the airport set up monitoring mechanism to monitor any novel coronavirus caused severe respiratory disease suspected cases."

The spokesman stressed: "Hong Kong has found no cases of human infection with the virus."

The spokesman advised travelers to Hong Kong, such as from the countries affected by the new coronavirus and respiratory symptoms should wear a mask and seek medical attention to the doctors to report their travel history.  http://www.dh.gov.hk/tc_chi/press/2013/130222-2.html

Goats: potential carriers of the new coronavirus?

02/22/2013

A Saudi man sits next to his sheep at an animal market in Riyadh in December 2008. (Fahad Shadeed/Reuters)

Scientists still have no idea how people are getting infected by the novel coronavirus, or which animal might be spreading it to humans.

But yesterday, Eurosurveillance published a paper detailing the investigation of a Qatari patient who was treated in Germany in October and November. And it had this interesting tidbit:

"The patient owned a camel and goat farm and reported a large number of casual contacts (approx. 50 persons per day) on a regular basis. He remembered that before his disease onset some goats were ill and had fever. He did not have direct contact with the goats or any other animals especially falcons or bats, but said he had eaten goat meat. He also reported to have had contact with one of his animal caretakers who was ill with severe cough and was hospitalised."

Since April 2012, the virus has infected 13 people and killed seven — cases so far have been linked with Qatar, Jordan and Saudi Arabia.

Evidence strongly suggests the new coronavirus originated in bats — and since people don't tend to hang around bats too much, scientists are also considering the possibility that the virus is passing to an intermediary animal which, in turn, is infecting humans.

In a previous Eurosurveillance paper, we learned that one of the first known coronavirus patients spent time on a ranch where there were camels and sheep — although he apparently didn't contact them directly. 

But in this latest report, one detail leaps out: the sick goats. When it comes to zoonotic diseases, unusual animal illnesses or deaths can act as warning signs for human outbreaks. Case in point, avian flu: when there is a human infection, chances are there will also be a lot of dead chickens nearby.

Dr. Anthony Mounts, the WHO's technical lead on the novel coronavirus, said goats — and camels — are definitely among the animals investigators are poking and prodding in their search for the virus.

"We don't really know where this virus is lurking, what kind of animal it might be circulating in," he said. "But certainly, if you had a sick animal that someone had been exposed to, that would really raise a red flag."

But he points out that there are multiple routes a virus could take to get into people. Nipah virus, for example, is a bat virus that can infect pigs, which have caused human outbreaks in Malaysia and Singapore; but in Bangladesh, studies have suggested that people there are getting infected by drinking raw palm date juice collected in clay pots -- which fruit bats like to slurp from at night.

Aside from this latest Eurosurveillance report, Mounts said he is not aware of any other reports of unusual animal illnesses or deaths that might be linked to the novel coronavirus.

The goats — they "could just be a red herring," Mounts said. "It could be that there are different sources, different routes of transmission."   http://thestar.blogs.com/worlddaily/2013/02/goats-and-camels.html

Epidemiological update: additional case of severe lower respiratory tract disease associated with a novel coronavirus in Saudi Arabia

Epidemiological update: additional case of severe lower respiratory tract disease associated with a novel coronavirus in Saudi Arabia

22 Feb 2013

ECDC On 19 February 2013, the Ministry of Health in Saudi Arabia has informed the World Health Organization (WHO) about an additional confirmed case of novel coronavirus (NCoV) infection. The patient was admitted to hospital on 29 January 2013 and died on 10 February. An investigation by the Ministry of Health in Saudi Arabia is on-going. This case has been notified through the International Health Regulation (IHR) on 20 February 2013. Since April 2012, thirteen cases of NCoV have been confirmed, including seven deaths. In the United Kingdom, the Health Protection Agency (HPA) is actively investigating the recent family cluster of cases to identify the possible route of infection and detect any additional secondary cases. Active follow-up of contacts of the three confirmed cases of the family cluster have not detected additional confirmed secondary cases by 22 February 2013. On 19 February, in light of the NCoV family cluster in the United Kingdom, the European Centre for Disease Prevention and Control (ECDC) has updated its risk assessment. This 13th case reported from Saudi Arabia does not change the ECDC assessment of the situation. ECDC is closely monitoring the situation in collaboration with WHO and the European Member States. http://ecdc.europa.eu/en/press/news/Lists/News/ECDC_DispForm.aspx?List=32e43ee8-e230-4424-a783-85742124029a&ID=851&RootFolder=/en/press/news/Lists/News

Guizhou another bird flu death

Guizhou another bird flu death the Government to strengthen the prevention and control of infectious diseases

Feb 22, 2013 8:47 PM

 Guiyang, February 22 (Reporter Wang Chao Yang Qian) 22 afternoon, Guizhou Province, another human cases of avian influenza were due to disease progression, the Second People's Hospital of Guiyang rescue died. Guizhou Province did not report new human bird flu prevention and control work into the norm.

　　February 10, Guizhou Provincial Health Department Bulletin, Guiyang confirmed two cases of human infection of highly pathogenic avian influenza cases. Patients Shuai Peng months, female, 21 years old, February 2, transferred to Guizhou Provincial People's Hospital intensive care unit treatment. Patients Cai as a mountain, male, 31 years old, the February 3 disease drugs, self-serving healed, from 8 am to Guiyang City People's Hospital for treatment and later transferred to the hospital intensive care ward for treatment. February 10, after a review of detection of two respiratory specimens confirmed positive for human avian influenza virus H5N1 nucleic acid.According to the survey, case history of close contact with poultry.

　　Two of the patients, respectively, at 13 and 22 days after she died.On the 17th, in close contact with the two patients 110 close contacts all the lifting of medical observation, none of fever and other abnormal clinical manifestations. Far, Guizhou not received a report of a new outbreak of avian flu.

　　22, the Guizhou provinci.. http://www.chinanews.com/jk/2013/02-22/4589092.shtml

Guizhou, a male human bird flu patients died from

February 22, 2013 20:53:33
Source: Xinhua


　　Guiyang, Xinhua, February 22 (LI Jing Asia) Guizhou recently confirmed two human cases of avian flu patients, female patients died on the 13th, another male patient died on the 22nd death.

　　Reporter learned from the Guizhou Provincial Health Department, 31-year-old male patient Cai, before his death in Guiyang City, a KTV waitress, February 3rd onset to Guiyang Jinyang hospital on the 8th, the 10th, the expert group confirmed human infected with the highly pathogenic avian influenza. At 16:40 on the 22nd, due to multiple organ failure, died in the hospital of Jinyang death.

　　It is understood that the two patients were alive with birds history of close contact, and are at ..
http://big5.xinhuanet.com/gate/big5/..._114772091.htm

WHO: Risk of new coronavirus infection remains unchanged

Posted on February 22, 2013, Friday

Read more: http://www.theborneopost.com/2013/02/22/who-risk-of-new-coronavirus-infection-remains-unchanged/#ixzz2LaHxkZmeA World Health Organisation (WHO) spokesman said the risk of the novel coronavirus infection remains unchanged but urged health authorities to remain vigilant, Xinhua news agency reported.

“We have not seen sustained human to human (h2h) transmission and three instances of limited h2h transmission do not necessarily mean there will eventually be sustained h2h transmission,” said spokesman Gregory Hartl said.

Read more: http://www.theborneopost.com/2013/02/22/who-risk-of-new-coronavirus-infection-remains-unchanged/#ixzz2LaHmoRzu

Vietnam MOH has officially launched the warning about corona virus

Can be cured by a new virus like SARS

Friday, 22/02/2013 07:12

ANTD - Department of Health - Ministry of Health has officially launched the warning about severe acute respiratory disease caused by the corona virus. 

TS. Tran Thanh Duong, Deputy Director, Department of Preventive Medicine, said up to this point in our country has not detected any cases of coronaviruses, a dangerous virus like SARS.However, the risk of epidemic spread and actively prevent the pandemic virus in Vietnam, the Ministry of Health has written proposal to strengthen the international medical quarantine at borders to detect and isolate suspected cases of coronavirus infection. PhD. Tran Thanh Duong said, as notified by the World Health Organization (WHO), from  22-9-2012 to 16-2, the world has recorded 12 cases positive for the corona virus, which has 5 deaths in Saudi Arabia, Jordan and the United Kingdom. 15-2, in the UK confirmed one case of new infections and to determine the corona virus is spread from person to person (family has had 2 previous coronavirus infections). 

According to Yang, the health sector in Vietnam was able to test samples to find out what kind of new virus. If corona virus-infected patients, the health of our country is completely curable.  

http://www.anninhthudo.vn/Khoe-dep/Co-the-chua-duoc-benh-do-virus-moi-giong-SARS/486939.antd

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Bartan appeared to avian influenza in emerging Valley Governorate

22-02-2013 - 12:58 AM

Dr Mohammed Bashir, Director General of Veterinary Medicine in the New Valley that when the passage of commissions of inquiry for bird flu Educational household Baforeigp committees suspected that there are symptoms of avian influenza.

The Directorate took samples from infected birds and sent on the same day to the laboratory reference for controlling the production of poultry in Cairo and will be held on 19.02.2013 and emerged as a result lab positive disease and was immediately assigned committees of doctors Veterinary Department Baforeigp to get rid of birds remaining execute her to cleanse the place with disinfectant was notified Directorate of Health Affairs for the detection of contacts of these birds and take samples of nearby houses to be sent to labs for testing where Bartan appeared to bird flu in emerging Valley Governorate.

Today, the launch of the Department of Veterinary Medicine in New Valley Governorate to Agraeamlah cleansing and elimination of the disease to prevent its spread.

http://onaeg.com/?p=611791

Saudi Arabia reports to WHO another death of confirmed new coronavirus infection

GENEVA, Feb. 21 (Xinhua) -- The Ministry of Health in Saudi Arabia has informed the World Health Organization (WHO) of another death of confirmed infection with the novel coronavirus, WHO announced Thursday evening.

The patient was hospitalized on Jan. 29 and died on Feb. 10. Further investigation into this case is ongoing, WHO said in its latest disease outbreak update.

To date, WHO has been informed of a total of 13 confirmed cases of human infection with the new coronavirus, including seven deaths.

In Britain, where three family members had been confirmed with new coronavirus infection and one of them died, the Health Protection Agency continued to carry out investigations, WHO said.

In a newly-published article in American online journal mBio, researchers in the cantonal hospital in St. Gallen, Switzerland said that the novel coronavirus can reach its peak ability to replicate in two days, compared with as much as four days for the SARS virus.

WHO spokesman Gregory Hartl told Xinhua Thursday that the speed of replication of the virus is not related with its actual ability to spread.

He also reiterated that a comparison between the new virus and SARS virus is "not helpful".

He said that the novel coronavirus which we are seeing now is different genetically from SARS, it does not transmit as easily as SARS did, there are many fewer cases for the time-being of this novel coronavirus, and it causes a different spectrum of disease in some patients.

"So the two viruses are not the same," he said.

"We prefer to say that the two viruses are from the same family of coronaviruses, but that is where comparisons stop," he said.

Hartl said on Wednesday that the risk of the novel coronavirus infection is unchanged but urged health authorities to remain vigilant as it is impossible to predict the future.

WHO continues to closely monitor the situation, it said in the update.  http://news.xinhuanet.com/english/world/2013-02/22/c_132183971.htm

Canada-Statement from Dr. Arlene King, Chief Medical Officer of Health

Novel Coronavirus

Statement from Dr. Arlene King, Chief Medical Officer of Health

February 21, 2013 6:00 pm

Ministry of Health and Long-Term Care

The Ministry of Health and Long-Term Care, in collaboration with Public Health Ontario (PHO) and the Public Health Agency of Canada (PHAC), is closely monitoring the small number of cases of novel (or new) coronavirus reported globally.

To date, there have been no cases of novel coronavirus detected in Ontario or Canada and the risk to Ontarians of contracting this virus remains very low.

Although the majority of cases identified are in individuals who have travelled to or reside in Saudi Arabia, Jordan or Qatar, two recent cases in the United Kingdom appear to have acquired the virus through contact with a relative with recent travel history to Pakistan and Saudi Arabia.

While the recent cases identified in the United Kingdom suggest evidence of person-to-person transmission, no sustained transmission has been identified.

No special travel restrictions have been implemented and Ontarians are advised to follow normal precautions to protect themselves and others from the spread of germs and influenza like illness, including: frequent hand washing, proper cough and sneeze etiquette and up-to-date immunizations.

Coronaviruses are common and are typically associated with mild upper respiratory illness, such as the common cold. Although rare, some strains of coronaviruses produce more severe illnesses, and could cause death.

The Ministry of Health and Long-Term Care will continue to work with our health partners to monitor this issue and will continue to share any further advice or updates with health professionals and the public.

To keep informed on any new developments, please visit Information for Health Workers regularly for updates.  

http://news.ontario.ca/mohltc/en/2013/02/novel-coronavirus.html