Treyfish's H5N1 Pandemic Information News

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Two more cases of AI confirmed

2014-02-09 19:49
Two more cases of bird flu were confirmed on Saturday despite quarantine efforts, raising further concerns over the virus spreading, officials said.

According to the Ministry of Agriculture, Food and Rural Affairs, more than 10,000 fowl at two farms, in Yeongam-gun, South Jeolla Province, and Hwaseong, Gyeonggi Province, were found to have been infected with the highly pathogenic strain of H5N8.

The virus suspicions were reported last Thursday from the two farms after a large number of poultry was found dead.

The quarantine authorities immediately culled more than 150,000 fowl being raised in a 500-meter radius of the concerned sites. Additional culling of more than 100,000 fowl within a 3-kilometer radius is underway, officials said.

As of Sunday afternoon, more than 100 suspected cases have been identified in the country since the first outbreak on Jan. 16, with 51 cases confirmed.

More than 3 million poultry have been slaughtered since then.

Meanwhile, North Korea is also stepping up efforts to defend against the spread of the virus amid concerns over the bird flu, the North Korean media said. According to the North’s state-run Rodong Sinmun newspaper on Saturday, the government is taking preventive measures.

“The quarantine department has drafted a meticulous plan to protect the state from infectious diseases such as bird flu,” it said.

“An emergency meeting was held and revolutionary measures are being taken to prevent the virus spreading through raising local government’s responsibility and role.”

Last week, the North’s official Korean Central News Agency also reported that the state is monitoring the movement of migratory birds and conducting tests on farm visitors and poultry as part of efforts to stave off the outbreak.

The media, however, has not confirmed whether avian influenza has broken out in the isolated state.

According to the World Health Organization’s report late last month, the bird flu has not become a threat for North Korea yet.

Observers said the virus’ spread in neighboring countries such as South Korea and China led North Korea to step up its preventive efforts. http://www.koreaherald.com/view.php?ud=20140209000255

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08 022 014

Minya Governorate haunt these days, a state of terror and panic, following the spread of swine flu in Minia Governorate, especially after suspected, in the injury of 9 prisoners, and taken to the Fever Hospital, and isolated and subjected to examination and analysis.

The director of the hospital admitted that the hospital received Minya 9 prisoners under heavy guard, is suspected of having swine flu.

Prevailed in a severe case of panic among the people of North Center Matay after the emergence of 3 cases of bird flu.

The people of the center yesterday they were surprised by the appearance of three cases of bird flu, which has pushed a lot from the people, the slaughter of large numbers of infected birds.

The official confirmed the Directorate of Veterinary Medicine in Minia Governorate, it was suspected cases of 3 cases of bird flu, a sample was taken from infected birds, but that the people were very condition of horror and dismay, before they emphasized that the result is negative.

And rushed a lot of parents, to the pharmacy to search for drug Altamflo anti-virus. http://translate.google.com/translate?sl=ar&tl=en&js=n&prev=_t&hl=en&ie=UTF-8&u=http%3A%2F%2Fwww.zawya.com%2Far%2Fstory%2F%25D9%2585%25D8%25B5%25D8%25B1_%25D8%25A5%25D8%25B4%25D8%25AA%25D8%25A8%25D8%25A7%25D9%2587_%25D9%2581%25D9%2589_%25D8%25A5%25D8%25B5%25D8%25A7%25D8%25A8%25D8%25A9_12_%25D8%25A8%25D8%25A5%25D9%2586%25D9%2581%25D9%2584%25D9%2588%25D9%2586%25D8%25B2%25D8%25A7_%25D8%25A7%25D9%2584%25D8%25AE%25D9%2586%25D8%25A7%25D8%25B2%25D9%258A%25D8%25B1_%25D8%25A8%25D8%25A7%25D9%2584%25D9%2585%25D9%2586%25D9%258A%25D8%25A7-ZAWYA20140208123747%2F

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Reporter yesterday from (Xuzhou) Municipal Health Bureau, the city a patient diagnosed with H7N9 avian influenza infection.
Huan patient, male, 63 years old, currently residing in Gulou District of Xuzhou City, February 6, Xuzhou diagnostic expert group confirmed cases of the H7N9 bird flu human cases of infection. Patients January 29 symptoms of fever, cough after February 1 city itself to a hospital for treatment and hospitalization, the patient is currently in critical condition.

Patients were retired workers, had been to the farmers market, and the home of self-support "ingot" chicken 6, there is history of exposure to poultry. The health sector has rapidly implement measures to deal with the epidemic. After investigation, the close contacts of the cases there were 11 people, as of now no exception... http://translate.googleusercontent.com/translate_c?depth=2&hl=en&ie=UTF8&prev=_t&rurl=translate.google.com&sl=auto&tl=en&u=http://www.chinanews.com/gn/2014/02-07/5807325.shtml&usg=ALkJrhgMzuYIkIcSZg_1acOA0sreCPPWIg

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....Add six cases during the Spring Festival in Hangzhou
February 6, Zhejiang Provincial Health and Family Planning Commission informed the province added two cases of human infection with H7N9 avian influenza. Patients Jiang Moumou, male, 64 years old, Anji County, Huzhou, February 5 confirmed cases of human infection of H7N9 avian influenza. Now the condition is severe, treatment in a hospital in Hangzhou. Patients Zheng Moumou, male, 39 years old, currently residing in Deqing County, Huzhou, February 5 confirmed cases of human infection of H7N9 avian influenza. Now the condition is severe, treatment in a hospital in Hangzhou.
According to statistics, from January 31 to start the New Year on February 6 Year 7, the Spring Festival week, the province confirmed 13 cases of H7N9 cases. These patients were from Hangzhou, Huzhou, Shaoxing, Wenzhou, Jinhua and Taizhou, where 11 cases were male, Hangzhou cases up to a total of six.... cases. http://translate.googleusercontent.com/translate_c?depth=2&hl=en&ie=UTF8&prev=_t&rurl=translate.google.com&sl=auto&tl=en&u=http://www.hangzhou.gov.cn/main/zwdt/bmdt/ww/T473450.shtml&usg=ALkJrhiOyNEJUgkw1Tity-byD3BfGuieTQ

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Zhejiang: 73 cases (12 cases died Jan. 27 deadline)

Guangdong: 55 cases (12 patients died)

Fujian: 14 cases (1 death)

Jiangsu: 11 cases (1 death)

Shanghai: 8 cases (4 deaths)

Hunan: five cases (1 death)

Guangxi: 3 cases (deaths 0 cases)

Beijing: two cases (1 death)
http://translate.googleusercontent.com/translate_c?depth=2&hl=en&ie=UTF8&prev=_t&rurl=translate.google.com&sl=auto&tl=en&u=http://business.sohu.com/20140207/n394549051.shtml&usg=ALkJrhiywb-xXrLJ-7EEcXg_sdNDXPCLjA

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Effect of closure of live poultry markets on poultry-to-person transmission of avian influenza A H7N9 virus: an ecological study

Hongjie Yu MD a †, Joseph T Wu PhD e †, Dr Benjamin J Cowling PhD e

, Qiaohong Liao MD a, Vicky J Fang MPhil e, Sheng Zhou MD a, Peng Wu PhD e, Hang Zhou MD a, Eric H Y Lau PhD e, Danhuai Guo PhD f, Michael Y Ni MPH e, Zhibin Peng MD a, Luzhao Feng MD a, Hui Jiang MD a, Huiming Luo MD b, Qun Li MD c, Zijian Feng MD c, Yu Wang PhD d, Dr Weizhong Yang MD d

, Prof Gabriel M Leung MD e

Summary

Background

Transmission of the novel avian influenza A H7N9 virus seems to be predominantly between poultry and people. In the major Chinese cities of Shanghai, Hangzhou, Huzhou, and Nanjing—where most human cases of infection have occurred—live poultry markets (LPMs) were closed in April, 2013, soon after the initial outbreak, as a precautionary public health measure. Our objective was to quantify the effect of LPM closure in these cities on poultry-to-person transmission of avian influenza A H7N9 virus.

Methods

We obtained information about every laboratory-confirmed human case of avian influenza A H7N9 virus infection reported in the four cities by June 7, 2013, from a database built by the Chinese Center for Disease Control and Prevention. We used data for age, sex, location, residence type (rural or urban area), and dates of illness onset. We obtained information about LPMs from official sources. We constructed a statistical model to explain the patterns in incidence of cases reported in each city on the basis of the assumption of a constant force of infection before LPM closure, and a different constant force of infection after closure. We fitted the model with Markov chain Monte Carlo methods.

Findings

85 human cases of avian influenza A H7N9 virus infection were reported in Shanghai, Hangzhou, Huzhou, and Nanjing by June 7, 2013, of which 60 were included in our main analysis. Closure of LPMs reduced the mean daily number of infections by 99% (95% credibility interval 93—100%) in Shanghai, by 99% (92—100%) in Hangzhou, by 97% (68—100%) in Huzhou, and by 97% (81—100%) in Nanjing. Because LPMs were the predominant source of exposure to avian influenza A H7N9 virus for confirmed cases in these cities, we estimated that the mean incubation period was 3·3 days (1·4—5·7).

Interpretation

LPM closures were effective in the control of human risk of avian influenza A H7N9 virus infection in the spring of 2013. In the short term, LPM closure should be rapidly implemented in areas where the virus is identified in live poultry or people. In the long term, evidence-based discussions and deliberations about the role of market rest days and central slaughtering of all live poultry should be renewed.

Funding

Ministry of Science and Technology, China; Research Fund for the Control of Infectious Disease; Hong Kong University Grants Committee; China—US Collaborative Program on Emerging and Re-emerging Infectious Diseases; Harvard Center for Communicable Disease Dynamics; and the US National Institutes of Health. http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2813%2961904-2/abstract?rss=yes

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By Adam Pasick @adampasick 12 hours ago

H10N8 is the latest bird flu to come out of China and, potentially, decimate humanity like in that Gwyneth Paltrow movie. You may have previously been mortally frightened by news about H1N1, which killed up to 100 million people in 1918 and another 15,000 in 2009 and 2010. Or maybe you’ve been reading about H7N9, which has been connected to just about 100 human deaths and is the cause of a massive poultry cull in Hong Kong this week:

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A health officer packs dead chickens at a wholesale poultry market in Hong Kong. Reuters/Tyrone Siu

Is H10N8 10 times more deadly than H1N1—or is it eight times, or 80? Not at all. The names refer to the two kinds of spiky protein that influenza A viruses wear on their surfaces, all the better to burrow into the hosts’ cells. H is for hemagglutinin and there are 16 varieties; N is for neuraminidase and there are nine different kinds. All told there are 144 different types of influenza A, from H1N1 to H16N9, all of which are found in birds and some of which are also found in horses, pigs, and humans.

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Information is beautiful

So why do new versions keep popping up to infect humans? That’s where promiscuous virus behavior comes in. The influenza A virus is fond of a little trick known as reassortment, which means that two viruses infecting the same cell can swap genetic components such as hemagglutinin and neuraminidase proteins. So a chicken in China (virtually all new influenza strains arise in southeast and eastern Asia because of the close contact between humans and livestock) that has two known flu types can give rise to a novel third strain.

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CDC

To complicate matters, a virus can mix and match any of its eight genes—not just the H and N proteins—and can incorporate genetic material from swine, avian, and human flu strains.

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virology.ws

In the case of H10N8, only one person has died and another has become sick, making it much too early to issue any apocalyptic warnings. But Chinese and global health authorities are carefully monitoring the virus—especially any indications that it is transmittable between humans, which is when the alarm bells really start going off.http://qz.com/174499/h10n8-bird-avian-flu/

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I am inclined to believe this.. The pace is not slowing, and I see funny stuff

February 6, 2014

The Guangxi health bureau said the boy, aged five and from Hengxian county, Nanning, started to show symptoms on Monday and was diagnosed with having the disease on Wednesday.

Health officials are still determining how the boy became infected but said he had been in close contact with his mother, 41.

She began to feel unwell late last month after visiting Zhongshan in Guangdong province. She returned to Nanning on January 28.

The boy remained in a stable condition but his mother’s condition was critical.

The above comments describe an H7N9 familial cluster in Hengxian county, Guangxi, which represents onward transmission of H7N9 bird flu exported from Zhongshan, Guangdong. Although the Guangxi MoH did note that the mother developed symptoms while in Zhongshan, the report on H7N9 confirmation in her son failed to note that the relationship between the two PCR confirmed cases. Although WHO has not reported either case, they did describe a similar family cluster in Zhongshan (father, 37M and daughter, 2F in Sanjiaozhen), and failed to note that the confirmed child was the daughter of a confirmed case.

The Guangxi cluster represents the first reported example of H7N9 export coupled with onward transmission, and the export from Zhongshan represents the first example of the H7N9 linkage between an area with one H2H familial cluster (Zhongshan, Guangdong) to another area (Hengxian, Guangxi) with another H2H familial cluster.

These important developments were withheld by the Guangdong MoH, Guangxi MoH, and WHO by the concealing of the relationships in the two familial clusters.

The glaring lack of transparency by the agencies reporting H7N9 confirmed cases while hiding H7N9 clusters is cause for many serious concerns. http://www.recombinomics.com/News/02061402/H7N9_GD_GX_Onward.html?utm_source=dlvr.it&utm_medium=twitter

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were 12 cases of death

Source: 21CN 2014-02-06 09:17

Share to: I want to Tucao

Keywords: Guangdong ten consecutive days, reports of human infection with H7N9 cases, 12 cases of death

Yesterday, the Ministry of Health and Family Planning Commission official website of the latest Bulletin, Zhaoqing, Foshan, Shenzhen City, a total of three new H 7N 9 4 cases of avian influenza confirmed cases of human infection. Guangdong has reported confirmed cases of consecutive days, as of yesterday, Guangdong has reported 54 cases of human infection with H 7N 9 confirmed cases and 12 deaths.

According to statistics, Guangdong Province, Huizhou, since August 2013 the first reported case since, as of February 5, 2014, 54 cases were reported in Guangdong Province cases, cured 16 cases, 12 deaths (were living in Dongguan, Yangjiang, Guangzhou , Jiangmen, Meizhou, Foshan, Huizhou and Shenzhen). Statistics by patient residence, located in Guangzhou, six cases of cases, 17 cases in Shenzhen, Foshan and 10 cases, 4 cases of Huizhou, Dongguan three cases, four cases of Yangjiang, Meizhou one case, two cases of Jiangmen, Zhaoqing five cases, Zhongshan two cases.

Under the notification, new cases of the following people:
● Lee, female, 5 years old, now living Huaiji County, Zhaoqing City, February 4 confirmed that the current stable condition.
● Liang Yijun, male, 42 years old, workers, now living Huaiji County, Zhaoqing City, February 4 diagnosed, currently in critical condition.
● strict, male, 49 years old, self-employed, now living Gaoming District of Foshan City. February 4 confirmed that the current stable condition.
● Dengmou, male, 56 years old, unemployed, now living Longhua District. February 4 diagnosed, currently in critical condition.

Prevention and control
Lin Shaochun hosted epidemic prevention and control of human infection with the H7N9 leadership team meetings
Once localized outbreaks live bird markets firmly closed
Southern News reporter Xue Bing Ni yesterday afternoon, the provincial vice governor Lin Shaochun hosted the prevent
...
Expert
Flu-like symptoms to tell the history of exposure to poultry
Experts advise to wash your hands as soon as possible after contact with live poultry, etc.
Southern News reporter Wang Chengbo for H 7N 9 confirmed cases of human bird flu infection consecutive Shenzhen CDC experts said that the current situation is still sporadic, does not appear clusters of outbreaks, there is no evidence that can be pers...

Shenzhen diagnosed 18 cases of eight people live in the Longgang District
Southern News yesterday, the Shenzhen soared H 7N 9 confirmed cases of avian influenza infection in a person. Shenzhen diagnosed 18 cases (including Dongguan confirmed cases in the deep) lived in Longgang 8 cases. The youngest was 6 years old boy, who was 82 years old maximum.
Southern reporter Statistics found in Shenzhen have been seven confirmed cases were cured, one person died and 10 people in the existing hospital. In confirmed cases, 8 cases occurred in Longgang District, mainly in the South Bay, Phuket, two streets, Luohu District 4 cases. Futian District and Bao'an District have two cases, Longhua District 1 case, another case was diagnosed in Shenzhen, Dongguan.
Outbreak Communications

Zhejiang
Augmented by a further four cases
Southern News Zhejiang Provincial Health and Family Planning Commission Feb. 5 briefing, the province added four cases of human infection of bird flu H 7N 9, both February 4 confirmed cases, of which two were male, two were female; 3 condition is Severe, a man critically ill; 4 people minimum age was 35 years and a maximum of 67 years; currently three people in Hangzhou, a hospital, a man in Shaoxing, a hospital for treatment.
It is reported that since 2014, 71 cases have been confirmed in Zhejiang H 7N 9 people infected with bird flu. (New)

Fujian Province
Increased to 14 cases

Health and Family Planning Commission of Fujian Province, according to Xinhua News Agency, February 4 notification, the date of the new province confirmed case of human infection of bird flu H 7N 9. Currently, Fujian Province, people infected with H 7N 9 avian flu cases has increased to 14 cases. New cases are: patients Moumou, aged 36, mechanic, now living in Quanzhou Yongchun County, is currently in critical condition at a hospital in Quanzhou, isolation and treatment.

Guangxi
Diagnosed one case
According to Xinhua News Agency reporter on the 5th learned from the health department of Guangxi, Guangxi confirmed case of human infection of bird flu H 7N 9. Patients Li Moumou, female, 41 years old, Heng Xu Zhen Tao people since January 27 flu symptoms in Zhongshan City, Guangdong, January 28 back Heng, February 3 due to exacerbations Heng a hospital for treatment. Currently, patients in critical condition.

National guard Planning Commission:
Found no H7N9 virus from person to person

During the Spring Festival, according to Xinhua News Agency, the National Health and Family Planning Commission to actively guide the country to carry out human infection of bird flu H 7N 9 treatment and prevention work. Up to now, the vast majority of cases remain sporadic, the ability to have an effective human to human transmission of the virus was not found.
January 30, the National Health and Family Planning Commission held H 7N 9 people infected with bird flu prevention and control of the Leading Group Office meeting, on a really good job of cases during the Spring and early detection and treatment of severe cases where work has been re-deployed.
New cases of H7N9 nationwide yesterday
Zhejiang
Add four cases
2 male and 2 female
Fujian Province
Add one case
1 M
Guangdong
Add four cases
3 male and 1 female
Guangxi
Diagnosed one case
1 woman http://translate.google.com/translate?sl=zh-CN&tl=en&js=n&prev=_t&hl=en&ie=UTF-8&u=http%3A%2F%2Fnews.yesky.com%2Fhot%2F306%2F35977806.shtml

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H7N9: Each case must be informed, science and do not absence [2014-02-06]

Source: Netease news 2014-02-06 08:50

H7N9 briefing every case lead to "talk bird phobia"-style panic, the reason lies in the disclosure of information asymmetry: although normalization notification mechanism, but the corresponding science remained scarce.
Affected by H7N9, Guangdong and other places of live poultry sales slump, the poultry industry suffered heavy losses. Recently, Guangdong and other places poultry industry associations, companies jointly submitted an open letter to all levels of government, the request "to stop the implementation of each notification H7N9 cases, to avoid the outbreak of ultra-dense reports." Guangdong health department responded, "no legal basis to stop notification", but the outbreak information to the media downplayed the beginning: no longer active communication of information to the media to send cases, notification no longer appears in the word "live poultry contact history" and so on... http://translate.googleusercontent.com/translate_c?depth=1&hl=en&ie=UTF8&prev=_t&rurl=translate.google.com&sl=zh-CN&tl=en&u=http://news.yesky.com/hot/150/35977650.shtml&usg=ALkJrhjeEk5AgHU6kp6PSEmaOAgroJmBUQ

Unknown

Thursday, February 06, 2014 June 02

Shanghai doctor died only 31 years old this year, there are eight Zhejiang patients less than 50 years old

H7N9 virus mutates eyeing the young is it?

Experts said there is no evidence of human to human transmission

Profile picture

This year, the country has confirmed cases of human infection with H7N9 avian influenza 110 cases, 20 cases including Zhejiang, Guangdong, Shanghai death. Recently, our new weekly number of cases of human infection confirmed H7N9 bird flu outbreaks have been close to peak levels during the last year. Although the disease control experts noted that during the Spring Festival is not an outbreak of human infection with H7N9 bird flu, but the reporter Statistics found, H7N9 bird flu has been dropping. Only in Zhejiang Province, 26 cases infected in 8 patients younger than 50 years old. The youngest only 20 years old. Shanghai due to H7N9 avian influenza has been reported in the doctor's death, but also only 31 years old.
H7N9 bird flu tentacles young, because H7N9 virus mutates it? Relatively resistant to young people, why encounter the virus, also fall so fast?
Why multiply the young patients
Young families do not lianzhouzhuan overtime
In Zhejiang, for example, this year's bird flu confirmed in 26 patients, the reporter carefully divided about their ages: 20 to 29 years, 2; 30 to 39 years, 4; 40 to 49 years, 2; 50 to 59 years, 8; 60 to 69 years old, 5; 70 to 79 years old, 5 people. If you draw a line at 50 years old, young patients below 8 people; elderly patients above 18 people.
Overall, though, this year's H7N9 bird flu virus, and there is no special "preference" of young people, the proportion of infections of all ages, not particularly noticeable differences. But the young man must not be taken lightly, can not be considered independent of H7N9 avian influenza with their own, or they will be very dangerous.
Zhejiang University Hospital of Infectious Diseases Professor Liang Weifeng reminded that the young man looked at the body strong, but now to the end of the year, people with a lot of overtime, after some "lianzhouzhuan" office workers, fatigue, colds,
It is easy to let the H7N9 avian influenza virus has an opportunity.
So experts recommend: Young cold not carrying, be sure to pay attention to rest, drink plenty of water, so that the body's immune system to restore as soon as possible, so as to fight with the virus. If there is a continuous fever, it is best to go to hospital blood test, if not high leukocyte index, lung inflammation, and have had contact with poultry experience, the best retest H7N9 virus nucleic acid.
H7N9 virus could mutate it?
There is no evidence of human to human transmission, but still wary
Young filed, Shanghai doctors infection cases occurred, and the doctors have not come into contact with poultry, should H7N9 bird flu virus is showing signs of mutation? Reporter put the question thrown Professor Lu Hongzhou, deputy director of Shanghai Public Health Clinical Center.
Professor Lu Hongzhou said to now, there are no cases of extraordinary human transmission of avian influenza H7N9 occurred.
Late last year, Zhejiang Huzhou Wengxu there had been infected with H7N9 avian influenza have been confirmed cases, then, Li Lanjuan academician after consultation with relevant experts believe that between them are not mutually infected, there is no evidence of human to human transmission.
However, Professor Lu Hongzhou alert, H7N9 avian influenza virus from person to person in a limited capacity exists in theory, he repeatedly stressed that this feature has been recognized by the national authority of the experts. "The so-called limited human-to-human transmission capacity, is characterized by the level of gene sequencing of the virus up analysis." Professor Lu said.
It is reported that the gene sequence of H7N9 avian influenza virus has been announced. This is the last one from the Zhejiang University, State Key Laboratory diagnosis of infectious diseases hospital director Li Lanjuan academicians, isolated and uploaded to international genebanks.
Professor Lu Hongzhou told reporters that since the H7N9 bird flu virus since appeared, one of the country's experts are most concerned about is the thing, there is no monitoring of H7N9 virus mutation key nodes occur.
He believes that the new H7N9 virus in the blood
Coagulation fibroin, the 226th amino acid particularly critical amino acids of this site has the typical characteristics of the human influenza virus genes. Professor Lu Hongzhou, once the site of mutation, meaning the virus and human respiratory epithelial cells are easily combined, people may greatly increase the chance of infection, which is the successor of the will of people.
"This change will come when nobody predicted, but vigilance is necessary." Professor Lu Hongzhou said.
■ Related Links
According to Voice of China reported that the current virus is still no significant variation occurred. Currently H7N9 is still a sporadic, Zhejiang, Guangdong and other southern provinces relatively high.
China CDC epidemiology professor Zeng Guang, chief expert believes that the virus occurred in areas which have some chance; Feng Zijian, deputy director of the Centre stressed that three terms, H7N9 virus either from epidemiological or virological , are currently found no significant variation.
These three aspects: one is the ability to communicate is not more easily transmitted from birds to humans, is not it easier person to person? This has not changed, with seeing the same situation last year; second is independent of the variation is not more powerful? Lead to more serious after the onset? Severe cases and deaths occur more of? This situation did not appear; third is to see there is no antiviral drug resistance mutation. It still is alkyl resistant class of drugs, the neuraminidase inhibitors of drug sensitive. In other words, three aspects are not concerned about the variability of new changes. http://translate.google.com/translate?sl=zh-CN&tl=en&js=n&prev=_t&hl=en&ie=UTF-8&u=http%3A%2F%2Fwww.yznews.com.cn%2Fyzsbs%2Fhtml%2F2014-02%2F06%2Fcontent_543415.htm

Unknown · FEB. 4, 2014

By DONALD G. McNEIL Jr.FEB. 4, 2014

Cases of the new H7N9 avian influenza in China are surging alarmingly, flu experts warned this week.

There are now about 300 confirmed cases, with more appearing every day. Roughly a quarter of the victims have died.

The first human cases were reported only last March. By contrast, the H5N1 influenza virus, another lethal strain that jumped from birds to people, first appeared in 2003 and took almost five years to reach the 300-case mark.

“H7N9 is blowing right by H5N1,” said Michael T. Osterholm, director of the Center for Infectious Disease Research and Policy at the University of Minnesota. “I’m really worried about that.”

At the same time, an even newer avian flu in China has killed its first human victim. That strain, known as H10N8, has been confirmed in only two people — a 73-year-old woman who died in December but whose infection was confirmed later, and a 55-year-old woman from the same province hospitalized in January. Both had contact with live poultry.

(Influenzas are described by the shapes of two protuberances on their surfaces: the hemagglutinin “spike,” or “H,” that attaches to cells, and the neuraminidase “helicopter,” or “N,” that chops off receptors, allowing new viruses to escape. There are 18 known types of H and 11 of N.)

While the newer influenza virus is worrisome, a mere two cases is “a far, far cry” from the risk posed by H7N9, said Ruben Donis, chief of preparedness for the flu division of the Centers for Disease Control and Prevention. He noted that the H7N9 virus had infected people in 10 Chinese provinces and was close to the borders of Vietnam, Cambodia and other poor Southeast Asian nations less adept than China at flu surveillance.

Birds appear to be spreading the H7N9 virus more through their breath than through feces, the normal infection route, Dr. Osterholm said, which means that fecal-sample testing in live markets may miss cases.

Monitoring the spread of the H7N9 and H10N8 viruses is difficult because neither makes chickens sick. Poultry farmers resist testing because a positive test forces them to destroy flocks that appear healthy. By contrast, the H5N1 virus rapidly kills flocks, so farmers want it extinguished.

Although human-to-human transmission of the H7N9 virus has not been confirmed, there have been clusters of two or three cases within families.

Because some relatives were reported to have developed symptoms days later than others, Henry L. Niman, a flu watcher in Pittsburgh who monitors news reports, said the most likely explanation was that they infected each other.

Dr. Osterholm disagreed, saying family members could have been exposed to the same birds but fallen ill on different days. http://www.nytimes.com/2014/02/05/health/cases-of-new-deadly-bird-flu-surge-in-china-experts-say.html?_r=0

Unknown

Disease outbreak news

5 February 2014 - On 4 February 2014, the National Health and Family Planning Commission (NHFPC) of China notified WHO of eight additional laboratory-confirmed cases of human infection with avian influenza A(H7N9) virus, including two deaths. .

Details of the cases are as follows

Six of the cases are male. The age range is 4 to 84 years old. Cases were reported from Zhejiang (4), Guangdong (3) and Jiangsu (1). Three cases are currently in a critical condition, two cases are currently in a severe condition and one is currently in a mild condition. All cases are reported to have had a history of exposure to poultry or a live poultry market.

A 42 year-old man from Hangzhou City, Zhejiang Province, who became ill on 25 January and was admitted to hospital on 30 January. He is currently in a severe condition. The patient has a history of exposure to poultry.
An 84 year-old man from Hangzhou City, Zhejiang Province, who became ill on 24 January and was admitted to hospital on 28 January. He is currently in a critical condition. The patient has a history of exposure to poultry.
A 56 year-old man from Jinhua City, Zhejiang Province, who became ill on 24 January and was admitted to hospital on 1 February. He is currently in a severe condition. The patient has a history of exposure to a live poultry market.
A 51 year-old man from Shaoxing City, Zhejiang Province, who became ill on 27 January and was admitted on 1 February. He is currently in a critical condition. The patient has history of exposure to a live poultry market.
A 4 year-old girl from Zhaoqing City, Guangdong Province, who became ill on 26 January and was admitted to hospital on 3 February. She is currently in a mild condition. The patient has a history of exposure to live poultry.
A 76 year-old man from Yangjiang City, Guangdong Province, who became ill on 27 January and was admitted to hospital on 1 February. He died on 3 February. The patient had a history of exposure to live poultry.
A 52 year-old man from Huizhou City, Guangdong Province, who became ill on 25 January and was admitted to hospital on 2 February. He died on 3 February. The patient had a history of exposure to live poultry.
A 59 year-old woman from Wuxi City, Jiangsu Province, who became ill on 26 January and was admitted to hospital on 29 January. She is currently in a critical condition. The patient has history of exposure to a live poultry market.

So far, there is no evidence of sustained human-to-human transmission.
The Chinese Government continues to take the following surveillance and control measures:

strengthen surveillance and situation analysis;
reinforce case management and treatment;
conduct risk communication with the public and release information;
strengthen international collaboration and communication; and
conduct scientific studies.

Sporadic human cases

While the recent report of avian influenza A(H7N9) virus being detected in live poultry imported from the mainland to Hong Kong SAR, shows the potential for the virus to spread through live poultry, at this time there is no indication that international spread of avian influenza A(H7N9) has occurred through humans or animals.
Further sporadic human cases of A(H7N9) infection are expected in affected and possibly neighbouring areas, especially given expected increases in the trade and transport of poultry associated with the Lunar New Year.

WHO advice

WHO advises that travellers to countries with known outbreaks of avian influenza should avoid poultry farms, or contact with animals in live bird markets, or entering areas where poultry may be slaughtered, or contact with any surfaces that appear to be contaminated with faeces from poultry or other animals. Travellers should also wash their hands often with soap and water. Travellers should follow good food safety and good food hygiene practices.
WHO does not advise special screening at points of entry with regard to this event, nor does it currently recommend any travel or trade restrictions.
As always, a diagnosis of infection with an avian influenza virus should be considered in individuals who develop severe acute respiratory symptoms while travelling or soon after returning from an area where avian influenza is a concern.
WHO encourages countries to continue strengthening influenza surveillance, including surveillance for severe acute respiratory infections (SARI) and to carefully review any unusual patterns, in order to ensure reporting of human infections under the IHR (2005), and continue national health preparedness actions.

Current technical information as well as guidance related to avian influenza A(H7N9) can be found at the WHO web site:

Unknown

English.news.cn 2014-02-05 21:56:45

BEIJING, Feb 5 (Xinhua) -. Eleven Chinese people were confirmed to be infected with the H7N9 bird flu on Wednesday in four regions, with 8 in critical condition, according to local health authorities.
The southern province of Guangdong reported 4 new cases, including a 5-year-old girl and a 42-year-old man in Zhaoqing City, a 49-year-old man in Foshan City and a 56-year-old man in Shenzhen City, said the provi... http://translate.googleusercontent.c...Up4gR66lke-I_g

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Xinhua Hangzhou, February 5 (Reporter Zhang Le) reporter on the 5th from the Zhejiang Provincial Health and Family Planning Commission was informed that since January 30 to February 5, Zhejiang notified added 13 cases of human infection with H7N9 avian influenza.
So far, this year, Zhejiang has a total 69 cases of human infection with the H7N9 briefing bird flu epidemic continued to show a high degree of dissemination of state.
Water certain patients, male, 75 years old, farmer, Yinzhou District, Ningbo people. January 30 was infected with H7N9 briefing confirmed human cases of avian influenza. Is now in critical condition, a hospital for treatment in Ningbo.
Patients Lin Moumou, male, 76 years old, retired, Zhenhai District, Ningbo people. January 30 was infected with H7N9 briefing confirmed human cases of avian influenza. Now the condition is severe, in Ningbo, a hospital for treatment.
In certain patients, male, 78 years old, farmer, Yuhang District of Hangzhou people. January 30 was infected with H7N9 briefing confirmed human cases of avian influenza. Is now in critical condition, in Hangzhou, a hospital for treatment.
Patients Moumou, male, 64 years old, retired, Jiangbei District, Ningbo people. January 30 was infected with H7N9 briefing confirmed human cases of avian influenza. Is now in critical condition, a hospital for treatment in Ningbo.
Patients You Moumou, male, 44 years old, farmer, Taizhou Huangyan people. February 2 was notified diagnosed human cases of avian influenza H7N9 infection. Now the condition is severe, in Taizhou, a hospital for treatment.
Patients Mo XX, male, 42 years old, Binjiang District, Hangzhou people. February 4 confirmed human infections have been notified cases of avian influenza H7N9. Now the condition is severe, treatment in a hospital in Hangzhou.
Patients Han Moumou, male, 84 years old, Yuhang District of Hangzhou people. February 4 confirmed human infections have been notified cases of avian influenza H7N9. Is now in critical condition at a hospital in Hangzhou treatment.
Patients Wu Moumou, male, 56 years old, Wu Jinhua city people. February 4 confirmed human infections have been notified cases of avian influenza H7N9. Now the condition is severe, treatment in a hospital in Hangzhou.
Money certain patients, male, 51 years old, Shaoxing Bridge District people. February 4 confirmed human infections have been notified cases of avian influenza H7N9. Is now in critical condition at a hospital in Hangzhou treatment.
February 5th, Zhejiang Provincial Health and Family Planning Commission informed the four cases of infection.
Patients Lin Moumou, male, 67 years old, Shaoxing City people. Now the condition is severe, treatment at a hospital in Shaoxing.
Patients Wu Moumou, female, 35 years old, Pingyang County, Wenzhou people. Now the condition is severe, treatment in a hospital in Hangzhou.
Patients Ma Moumou, female, 59 years old, Hangzhou, Fuyang City People. Now the condition is severe, treatment in a hospital in Hangzhou.
Patients Xu X, male, 49 years old, now living Gongshu. Is now in critical condition at a hospital in Hangzhou treatment. http://translate.googleusercontent.com/translate_c?depth=2&hl=en&ie=UTF8&prev=_t&rurl=translate.google.com&sl=auto&tl=en&u=http://news.xinhuanet.com/2014-02/05/c_119216384.htm&usg=ALkJrhiSjwBXgo3sEBREw7z79WdWcK3c4g

Unknown

..Health authorities in Guangxi province confirmed a boy had contracted the H7N9 strain of bird flu, a day after his mother was confirmed to have the virus.
The Guangxi health bureau said the boy, aged five and from Hengxian county, Nanning, started to show symptoms on Monday and was diagnosed with having the disease on Wednesday.
Health officials are still determining how the boy became infected but said he had been in close contact with his mother, 41.
She began to feel unwell late last month after visiting Zhongshan in Guangdong province. She returned to Nanning on January 28.
The boy remained in a stable condition but his mother’s condition was critical.
Xinhua reported the national health commission said there was no proof the H7N9 was spreading sustainably from person to person.... http://www.scmp.com/news/china/article/1421673/guangxi-boy-confirmed-h7n9-virus-after-mother-contracts-bird-flu

Unknown · **OK..If you say so...**

OK..If you say so...

By Esther Tanquintic-Misa | February 4, 2014 4:59 PM EST

Because of a susceptibility gene, emerging and getting rampant H7N9 flu virus may only infect residents of China.
A report published in the journal Clinical Infectious Diseases by Dr David Hui of the Chinese University of Hong Kong said H7N9 flu virus spreads easily and more among the Chinese because of the IFITM3 gene (interferon-induced transmembrane protein-3 gene).

View Full Image

REUTERS Health officials in protective suits put a goose into a sack as part of preventive measures against the H7N9 bird flu at a poultry market in Zhuji, Zhejiang province January 5, 2014. The local government ordered all live poultry be killed at two markets in Zhuji after a 34-year-old woman was confirmed to be infected with the H7N9 virus on Saturday, local media reported. Picture taken January 5, 2014.

The IFITM3 gene is the one that increases influenza disease severity. It is more predominant among the Chinese people. Caucasians hardly have them, Mr Hui said.
This seemed to confirm an earlier study that said one factor the Chinese are susceptible to the H7N9 flu virus was because they have lower levels of an immune protective mechanism known as CD8+ T lymphocyte (CTL) immunity.
Dr Hui said that 70 per cent of Chinese patients who had experienced severe influenza infection had the IFITM3 susceptibility gene, which could explain the emergence or presence of infection clusters among family members.
"Because the risk genotype occurs with such a high frequency [in Chinese people], its effect translates to a large population-attributable risk of 54.3% for severe infection in the Chinese population studied compared with 5.4% in Northern Europeans," Dr Hui said.

On Tuesday, China reported two new deaths due to the H7N9 flu virus. The death tally has now reached a total of 25 since January, while the number of human infections has reached 113 cases. Zhejiang and Guangdong were the areas most affected.
The new H7N9 virus emerged only last spring. http://au.ibtimes.com/articles/537199/20140204/china-research-h7n9-flu-virus.htm#.UvGjtfttaCk

Daniel Pye

Wed, 5 February 2014

Daniel Pye

A 5-year-old boy has tested positive for avian influenza, making the toddler the first reported case this year, the Ministry of Health and the World Health Organization said yesterday.
The boy, from Kampong Thom province’s Stung Sen district, was confirmed positive for the H5N1 virus on Sunday, the statement said.
The boy is in a stable condition after being admitted to the Jayavarman VII Hospital in Siem Reap town.
A government investigation into the case revealed that 200 chickens had mysteriously died in the boy’s village in mid-January, after which his parents had prepared the expired birds to eat.
“I urge parents and guardians to keep children away from sick or dead poultry and prevent them from playing with chickens or ducks,” Minister of Health Mam Bunheng said in the statement.
At least 22 cases of bird flu were recorded in Cambodia last year, according to the Ministry of Health. http://www.phnompenhpost.com/national/first-h5n1-case-2014-reported

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They isolated the virus and dubbed it A/Jiangxi-Donghu/346/2013(H10N8), or JX346 for short...

Genetic findings

The authors' genomic analysis of the virus showed that its hemagglutinin (H) protein was most closely related to that of a 2012 H10N3 duck isolate from Hunan province and that the neuraminidase (N) protein was most closely related to that of an H10N8 virus from a mallard in Korea.

All six of JX346's internal genes were closely related to those of H9N2 poultry viruses currently circulating in China, the authors found. But the internal genes were significantly different from those of previously reported H10 and N8 subtype viruses and were in different subclades from those of known H7N9 viruses.
Only two H10N8 viruses have been reported previously in China, one from a lake and the other from a poultry market, the report notes.

"H9N2 virus provided the internal genes not only for the H10N8 virus, but also for H7N9 and H5N1 viruses," the report says. "This relation should be studied further to understand the mechanism of how the internal genes of H9N2 virus transfer to viruses that infect people, and how the avian influenza virus transfers between species."
The authors say the findings suggest that JX346 might have originated from multiple reassortments between different avian flu viruses.

Senior author Yuelong Shu, PhD, of the Chinese Center for Disease Control and Prevention commented in a Lancet press release, "The H10 and H8 gene segments might have derived from different wild bird influenza viruses [that] reassorted to give rise to a hypothetical H10N8 virus in wild birds, which infected poultry and then reassorted with H9N2 viruses in poultry to give rise to the novel reassortant JX346 (H10N8) virus."
In other observations, the researchers say the patient's chronic medical conditions could have played a role in her death. But they found that the novel virus was "overwhelmingly dominant" in her tracheal specimens, which indicates that it was involved in her demise.

In addition, they found a mixture of glutamic acid and lysine at residue 627 in the virus's PB2 protein, a mutation that is associated with adaptation to, and can increase virulence in, mammals.
Further, the authors report that the novel virus preferentially binds avian-like alpha2,3-linked sialic acid receptors, which are "dominant in human lung tissue," suggesting a potential for the kind of lung damage found in human H5N1 infections....

http://www.cidrap.umn.edu/news-perspective/2014/02/study-h10n8-virus-first-human-case-novel-strain

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The Lancet, Early Online Publication, 5 February 2014