New bird flu scientists are puzzling

Unknown potential

• The virologist therefore calls for a ban on the import chicken from China, to which the EU has so far but could not bring.

On 1 April, the World Health Organization (WHO) first reported about the new flu virus, suffering from the first three people in eastern China.APAweb

Berlin / Beijing. This rampant in China new flu virus are experts worldwide mystery. "We do not understand why the virus causes this strange infections in humans," now said the German microbiologist Alexander Kekule from Halle. Was known to the scientists that viruses that are particularly aggressive to birds, occasionally jump to humans. The new variant of influenza virus A (H7N9) represents the common assumptions but on the head.

"Here it is that the virus causes almost no symptoms in birds," said Kekule, who heads the German Institute for Biosafety Research (IBS). And because the poultry is not apparent ill, the danger is great that infected chickens, ducks and pigeons are consumed.

And yet something seems troubling. "Due to the genetic analysis, we can say that the virus must have definitely found quite a long time in a human or other mammal, such as a pig," Kekule said. It had adapted so that it could better dock to the human cells in the airways.This obviously leads to severe diseases in humans.

Unknown potential

On 1 April, the World Health Organization (WHO) first reported about the new flu virus, suffering from the first three people in eastern China. Less than a month later, the WHO lists already 24 confirmed deaths and 126 laboratory-confirmed infections caused by A (H7N9).Some Asian countries have tightened their checks at airports.

Professionals face the fearful question whether the new flu virus could have the potential to cause a worldwide pandemic with potentially millions of deaths. There is not a clear answer.

Because in order to trigger a pandemic, a flu virus needs to change so that it spreads easily from person to person. With A (H7N9), experts see this not as a given. According to WHO, there has been no evidence of a "sustained human-to-human" transmission. Nevertheless deemed to be sure that people infected with the virus who had no contact with birds."Therefore, a transmission by another mammal, or rather by other people very likely," concludes Kekule.

But the virologists to view A (H7N9) still far from being classified as a horror virus. "The virus would definitely still go through some genetic changes before it would be able to trigger a pandemic." Positive leads to the expert that was not previously observed that H7 viruses spread in humans.

Severe pneumonia

Susanne also glassmakers from the German Robert Koch Institute (RKI) emphasized that a bird influenza virus can genetically change and adapt so that it will be transmitted from person to person, do not let yourself be predicted.

Currently, A (H7N9) resembles more the a few years ago occurred avian influenza virus A (H5N1), which was also performed in Europe in poultry farms to slaughter entire herds.Worldwide have died from bird flu since 2003, more than 370 people. Patients also suffer from the new flu severe pneumonia.

The previously reported infections are limited mainly to the metropolitan areas of Shanghai and Beijing, as well as five other Chinese provinces. But also in Taiwan, the disease occurred at a business man who had been in China. If and when the new influenza to Europe and Germany spill is unclear. "Individuals infected in China and Europe traveling cases can not be excluded," says RKI spokeswoman glassmakers.

Kekule warns, just because the virus is highly unusual, should apply extra care. The virologist therefore calls for a ban on the import chicken from China, to which the EU has so far but could not bring. The European Centre for Disease Prevention and Control (ECDC) advises travelers from China, of going to markets with animals, especially poultry markets.The direct contact with animals should be taboo. The rules of hygiene, such as frequent and thorough hand waxes are strictly adhered to. Kekule also urged to eat only well-cooked meat. http://www.wienerzeitung.at/themen_channel/wissen/forschung/542990_Neue-Vogelgrippe-gibt-Wissenschaftern-Raetsel-auf.html

NO EVIDENCE OF H7N9 HUMAN TO-HUMAN TRANSMISSION

Dr. Lee Norman on H7N9 Influe http://www.youtube.com/watch?v=gM6YZVe-NFA

Defence received a suspected H7 cases

2013-04-30 (18:21)

Centre for Health Protection of the Department of Health said that by 12:00 noon yesterday, 12 today, the CHP received a fulfilling reporting criteria of suspected cases of human infection with avian influenza A (H7), and one does not meet the reporting criteria cases .         Since March 31, the CHP received a total of 19 suspected cases of human infection with avian influenza A (H7) fulfilling the reporting criteria, as well as 44 cases fulfilling the reporting criteria.         A DH spokesman urged travelers should not visit the affected areas of live poultry market to avoid direct contact with poultry, birds or their droppings. Once exposed, you should wash your hands thoroughly with soap and water.         The spokesman stressed that there has been no confirmed cases of human infection with avian influenza A (H7N9) in Hong Kong.http://news.hkheadline.com/instantnews/news_content/201304/30/20130430a184320.html?cat=a

Free Salt

Ya'an earthquake zone exposure suspected victims of the avian influenza "flu everywhere"
WASHINGTON 2013 04 30] (The Epoch Times reporters Xia reported) H7N9 epidemic spread in a wide range of, as of April 29, has spread to 10 provinces a total of 125 cases of patients, in which 24 people died. After the Ya'an 4.20 earthquake, hit a large number of water pollution, resulting in people have reported diarrhea and other symptoms, and recently exposed the Ya'an disaster suspected H7N9 avian influenza, caused public panic. There are people in the disaster areas after the earthquake, "flu everywhere, are fever."

Quick Search Group - Treasure network share "at 5:02 on April 28 micro-Bo said: after the earthquake have been two cases of H7N9 avian influenza symptoms man, Li Chunlin, 49 years old, Ya'an; Chen Guangsong, aged 35 .Two patients have been admitted to the Central Hospital last night, Li Chunlin symptoms further aggravated.Preliminary view that the source of volunteers around the country, earthquake relief and donors were brought.

Communist China Family Planning Commission also claimed that on April 25, "does not exclude Yaan H7N9 avian influenza may occur. There are people, Ya'an earthquake, avian flu again! This day there is no way before.

The Ya'an hit Baoxing bee barrel Xiang salt Village Yang told the Epoch Times, told reporters: "I have heard of avian influenza, because of the earthquake everywhere busy, see flu everywhere, are fever, bad cold voice say the words. "

Mr. Yang also said that after the earthquake, villagers fever symptoms, high fever government directly to the hospital for the dozen, are middle-aged, and now still in hospital, I heard that isolated my child has a cold, has been coughing, very afraid of avian influenza. "

Mr. Huang the days thinking by the township, county Xingzheng village head also said that there are people have reported symptoms of fever, the disaster area disinfection to prevent the outbreak of large-scale epidemic.

China exposure after the earthquake dog anorexia hydrophobic village more than 200 dead in two days

Recently, the Ya'an days of the county think the township hundreds of testing water the safety of the drug testing goldfish "sudden death, highlighting the serious water pollution in the disaster areas. The same time, people in the disaster areas to the lack of tents, more than a dozen people share a tent, densely the victims worry if there is human-to-human disease, the consequences could be disastrous.

Baoxing County Rocker moraine Township very fact that, because of the damage to houses, victims desperately short of tents solve the housing problem.

Tent average 5-10 people a fifteen or sixteen people to live together, people just temporarily shower rain, there is no way only will Baoxing County salt Village Mr. Yang says. After the earthquake victims a child vomiting symptoms, many elderly symptoms such as cough and cold. Although not found epidemics, but the villagers are fears of avian influenza and other epidemics.

He also disclosed that home in days county think the township Xingzheng village from the day after the earthquake, not only in the death of fish in the fish tank, dogs and pigs in the village is also a large number of deaths.The second day of the earthquake, the water inside the water pipe into my fish tank, goldfish was poisoned. The dog starts anorexia hydrophobic, died two days later, a village two days more than 200 dead dog , Lushan County dog ​​die more, the Government is now everywhere in the dog injections, do not fight to put dogs to kill a lot of pigs killed in the earthquake. "

The official repeatedly hiding forbidden dilute the truth of the epidemic FNL Great Depression

The 24th Chinese Communist Party official declared that the H7N9 avian flu changed to weekly data from the daily newspaper, accused of attempting to play down the epidemic. Since the H7N9 avian influenza outbreak, the official Chinese Communist Party has repeatedly late, concealed data of the epidemic caused by a large number of people questioned, the people of Shanghai recently revealed to the media, social stability and people's hearts, ordering of avian influenza added a new and the number of deaths reported every day can not be more than two. Central Propaganda Department of the CPC for the April 20 earthquake reported in Ya'an also issued several strict control of the ban, prohibited from reporting negative news.

Ya'an 7.0 earthquake on April 20 around 8 o'clock, Sichuan Province 7 earthquake drill was held on April 19, assuming the earthquake zone around Ya'an and Chengdu and other places to expand. People questioned Chinese officials have predicted the earthquake, but did not publish notice to the people, just well prepared.

April 28, the Central Hospital of Wenzhou held human infection with the H7N9 avian influenza prevention and control of emergency drills, called to respond to large-scale epidemic. The matter resulted in a panic, the people said: Avian Influenza on the home front, it was very afraid!

People: Ya'an after the earthquake, and the case of avian flu! Too many disasters this year? What do we do?

H7N9 avian influenza has spread to Taiwan, April 24 confirmed the first case of H7N9 avian influenza. People worried about SARS in Taiwan staged again, calls upon the Government of Taiwan to strengthen protection, and people from the mainland into the control measures. Taiwan will be held on May 17 against market slaughter of live birds, people has changed their eating other meats.

(Editor: Liu Zhen)http://www.epochtimes.com/gb/13/4/30/n3859046.htm%E9%9B%85%E5%AE%89%E7%96%91%E7%8E%B0H7N9%E7%96%AB%E6%83%85-%E6%B0%91%E7%A7%B0%E9%9C%87%E5%90%8E%E2%80%9C%E6%B5%81%E6%84%9F%E5%88%B0%E5%A4%84%E9%83%BD%E6%9C%89%E2%80%9D.html

Exercise to guard against the new H7N9 outbreaks of the armed forces

Air Force Air hospital advocacy avian influenza prevention and control to increase the knowledge of teachers and students epidemic prevention

Military News Agency
April 2013 at 18:07



(Military News Agency reporters Jiang Dayu Kaohsiung Sari electricity) to guard against the new H7N9 influenza virus to cause outbreaks of the armed forces, the Air Force Institute of Aviation Technology held H7N9 influenza prevention and treatment advocacy activities, invited the Tri-Service General Hospital Family Medicine Medical Officer implementation of teaching so that teachers and students to learn how to do self-care, and the implementation of preventive work, the correct dimensional combat capability.
Chief Medical Officer Chen Weiliang in the course, indicating that the H7N9 flu virus, the clinical manifestations of the early symptoms of fever, cough and other respiratory tract infections, and then the development of severe pneumonia and breathing difficulties and other serious symptoms.
Chen Weiliang, before the first case of H7N9 flu cases, but there is still no direct evidence of human to human transmission, the cause has not been clear before, people should avoid contact with live poultry and birds keep their distance, edible meat must be cooked ; At the same time, the families of the officers and men after returning from the affected areas, resulting in fever, cough, body aches and other flu-like symptoms, consult a doctor immediately and inform the travel history, physician diagnosis and treatment. http://www.nownews.com/2013/04/30/11937-2932994.htm

The anti H7N9 avian influenza, fever antipyretics do not eat

The domestic first case of H7N9 avian influenza confirmed cases, Taichung City Government held this afternoon epidemic prevention meeting CDC area vaccination commander of light and analysis, the patients with fever on the 12th to taking Tamiflu until the 16th, the middle may be self- antipyretic.

He reminded buy antipyretics fever patients to the pharmacy, the pharmacist should be asked in detail, if infected area travel history or work history, birds, history of exposure, etc., should be referred to medical screening, do not sell antipyretics, lest temporarily fever medication, but affect the follow-up treatment.

Taichung City Health Bureau urged people fever Do not take antipyretics, especially to visit affected areas, people with a history of exposure to birds, if fever, cough and other flu-like symptoms should get medical screening.

全文網址: 防H7N9禽流感，發燒先別吃退燒藥 | H7N9停看聽 | 健康醫藥 | 聯合新聞網 http://udn.com/NEWS/HEALTH/HEA11/7866212.shtml#ixzz2RwaHzp6i
Power By udn.com http://udn.com/NEWS/HEALTH/HEA11/7866212.shtml

Taiwan Non-nationals H7N9 patients pay for their own medical fees

 "non-nationals will no longer afford medical expenses of H7N9 infection!" Department of Health Central Epidemic Command Center Commander Zhang Fengyi 30, May 1, non-nationals and did not have health insurance identity, infected with the H7N9 flu virus, the government only paid during the isolation ward fees, the virus inspection fees, antiviral agents and meal costs; remaining medical costs borne by the patient.

http://news.msn.com.tw/news3134062.aspx

Experts called on the elderly and the chronically ill avian influenza

CHP discuss the latest developments of the Mainland of human infection of H7N9 avian influenza, director of TH Leung said, yet the situation of human-to-human transmission, but the elderly and chronically ill patients, higher risk of infection.

Chairman of the Scientific Committee, Mr Yuen Kwok-yung, to remind the elderly to be careful.

http://hk.news.yahoo.com/%E5%B0%88%E5%AE%B6%E7%B1%B2%E9%95%B7%E8%80%85%E5%8F%8A%E9%95%B7%E6%9C%9F%E7%97%85%E6%82%A3%E8%80%85-%E6%8F%90%E9%98%B2%E7%A6%BD%E6%B5%81%E6%84%9F-102300979.html

China H7N9 cases rise to 127

One more infection has been reported in Southeast China’s Fujian province. That brings the total number of cases in China to 127.

The newest patient is a 58-year-old man, in serious condition. Medical professionals are tracing those who have had close contact with him. This is the third case detected in Fujian province, none fatal so far. On Monday morning, a patient died in Shanghai after testing positive less than two weeks ago. To date, 24 patients have died nationwide. Cases have been reported in 10 provinces on the Chinese mainland, and one in Taiwan. 

http://english.cntv.cn/program/newshour/20130430/102755.shtml?

Thermal scanners on standby at airports to anticipate H7N9 virus

The Jakarta Post, Jakarta | National | Mon, April 29 2013

A Health Ministry official said that the ministry had placed thermal scanners at all international airports in anticipation of an outbreak of the H7N9 virus, which recently hit mainland China as well as Taiwan.

“The equipment is ready, but there is an agreement with the World Health Organization (WHO) for countries in Southeast Asia to not activate the scanners just yet,” said Tjandra Yoga Aditama, director
general for disease control and environmental health at the Health Ministry, on Monday, as quoted by Antara news agency.

According to 2009 data, there are 27 international airports in  the archipelago.

He said the scanners would be activated  if the situation required the ministry to do so. He added that the ministry had also placed health officers at harbors as well as banners and posters.

“We have also checked on  APD and oseltamivir drugs. Hospitals have been asked to report any suspicious cases of severe acute respiratory infections to our office immediately,” he said.

According to reports, the H7N9 virus has infected 126 people in China, claiming 23 lives. (asw/dic)  http://www.thejakartapost.com/news/2013/04/29/thermal-scanners-standby-airports-anticipate-h7n9-virus.html

Fujian Province, the first case of human infection of H7N9 patients had contact with live chickens experts explain

...Daughter-in-law, transport, or sale of poultry, for He Gonggong help handling infected with H7N9, the daughter-in-law did not thing? Experts say, Luomou has over sixty years, compared with the young daughter-in-law, poor resistance, thus infected with H7N9.

In the morning of April 25, Longyan City, the agricultural sector in the patient's home and the surrounding poultry, sampling and testing of high Beizhen poultry market, not found in animal H7N9 avian influenza virus.http://www.fjsen.com/c/2013-04/29/content_11268245.htm

Shandong the H7N9 children with pulmonary edema four close contacts abnormalities

...Currently, Zhang's wife, is accompanied by his son isolated in a separate ward. Asked the child's current situation, she said, very good, very stable.Also with respect to the "double whammy", but witnessed children signs some comfort.　　Children with medical treatment team member Li Jinyuan to 29 also introduced children's lungs local edema symptoms, but her condition has been stable condition compared to the previous report in children is slightly heavier, but still are severe.

 4 who have flu-like disease for the mother, grandmother and two sisters　　It is understood that Zhang's two daughters are still in the home quarantine observation status. 　　29, according to the smooth introduction of Zaozhuang City, CDC director Road, Zhang's son cases, been identified close contacts and 4, respectively, mother, grandmother and two sisters. Currently, medical observation influenza like disease. 　　5 famous people, Zhang cases identified in the original health sector 12 close contacts of the column. It is understood that seven others were released on the 29th medical observation. Zhang's wife told reporters always liked the husband of the child's home in 16 -21 days fever during normal contact with the children, there is no special attention to.

 　　Open the way Shun, April 23, Zhang was diagnosed for the province's first case of H7N9 patients, disease control officers had close contacts acquisition throat swab samples for testing was negative, no flu-like symptoms found. Subsequently, in accordance with national medical observation process, they were quarantined at home and observe.Twice daily and a routine measure body temperature observed by the CDC staff. 　　
According to the smooth introduction of road, according to the process requirements, April 27 was originally the last day of the medical observation. In the morning, Interrupted no exception. In the afternoon, found children of low-grade fever of 37.2 ° C. CDC staff told me, I immediately feel the need to be vigilant. "Road Kai-shun disease control staff immediately arranged to come and sample the night that is found to be positive. 

Parent-child cases no causal association focuses on the detection win duration of treatment　　according to the process requirements of the national guard Planning Commission, fever 37.2 ℃ is not in the focus on the detection of the column. Special period of special performance, or disease control staff chances. Also proved that the medical treatment of Zhang's son won the time.Tall Sichuan, the provincial team leader, believes that Tamiflu within 48 hours, medical treatment is a good start. 　　Zhang's wife told reporters that morning, she first discovered the child's temperature 37.2 ° C, do not think, will be the first children to eat a little medicine, found that fever is not obvious very nervous after a few hours, reports the CDC, the relevant immediately rush over. Overnight testing showed positive 28, 8:00 pm, children with access to the Zaozhuang City Hospital for treatment under isolation. 

　　Current epidemiological investigation, found no necessary link between the cases of the father and son. "Road Kai-shun said that since found that since the first case of H7N9 patients, close contacts are done at least once a throat swab samples tested. In addition, the acquisition of high exposure the crowd samples tested over 50 cases, over 200 cases of environmental samples. , There is no causal link between the first case and in this case, up to the current results. This also confirms the industry's general view of the "no descendant of evidence". 　　Zhang's wife told reporters that the husband has improved and stable child will recover. Because "everyone to help us. http://roll.sohu.com/20130430/n374475636.shtml

No h2h in Shandong..

H7N9 avian influenza Latest news: Shandong parent-child cases significant differences difficult to witness descendant

Latest news of the H7N9 avian influenza, as of now, the Department of Shandong reported two cases of human infection with the H7N9 avian influenza confirmed cases, a parent-child relationship, this is the first time in Shanghai family gathering cases, experts said, that his father clinical symptoms difference , it is difficult to prove that the H7N9 avian flu virus can be transmitted person to person.

April 28 report of the Health Department of Shandong, Shandong new case of human infection of H7N9 avian influenza confirmed cases. Children Zhang, male, 4 years old, live in Zaozhuang City, and its parent Shandong Province on the 25th confirmed the first case of human infection of H7N9 avian influenza confirmed cases. According to the initial findings and conclusion of the study at home and abroad, has not yet found evidence of infection.

Obvious differences in parent-child symptoms

The father and son has illness, mean that H7N9 rendering the performance of human-to-human transmission? The provincial medical treatment team leader, Professor Gao Taichuan interview that the difference of the clinical symptoms of the Father and of the Son and of the two.

Professor Gao Taichuan describes the situation of children is relatively stable infection are pediatric emergency room treatment, eating and sleeping is relatively normal. Children showing the local symptoms of pneumonia, but her condition is not severe but not critically ill. According to the clinical diagnosis, the children viruses and bacteria combined infection, white blood cell count is high. Contrast diagnosis based on the beginning of the incidence and six hours later, the development of the children's condition and did not show the rapid deterioration of the situation.

Shandong second case of human infection of H7N9 patients did not enter the intensive care unit, but for isolation and treatment of infectious diseases in the hospital

"Taking the cure within 48 hours of onset, which is very timely." Tall Chuan said, according to the child's weight, the children have been taking a 45 mg dose of Tamiflu.

Zaozhuang City, director of Critical Care Medicine Li Jinyuan to introduce children are mild lung tissue damage, does not belong to the ranks of the severe. The children did not go into the intensive care unit for quality, but in Zaozhuang Municipal Hospital of Infectious Diseases, a separate ward for treatment. Li Jinyuan said that before the Beijing cure H7N9 avian influenza girl children, but children more serious cases than Beijing.

The progression of the disease but the children's father is unstable, on admission, no obvious pathological symptoms, but the hospital after 4 hours, the rapid development of the disease, the rate of deterioration soon. "Tall Chuan said the children's father after 7 days after emergency treatment, although not completely out of danger, but relatively stable vital signs, do not need the support of ECMO (artificial heart-lung machine).

No clear evidence of human-to-human transmission "

On a time basis, the children are the father hospitalized six days, was found to have a fever. As the original 12 in close contact with one of the children in the Interrupted been determined not showing flu-like symptoms, overwhelmed diagnosed is a "human-to-human transmission performance?

Tall Chuan, because the presence of a history of close contact, not directly related to exclude possible, but only from the point of view of symptoms, the gap between the two is obvious. Shandong Zaozhuang father and son have confirmed human infection of H7N9 avian influenza, at present, only from the point of view of clinical symptoms, father and son performance difference is obvious on avian flu "human-to-human transmission," saying there is no clear evidence to support. "

The same time, on a time basis, the degree of association of the symptoms of the father and son do not have the "human-to-human transmission performance. H7N9 avian influenza longest incubation period of seven days, the children in father hospitalized for 8 days, was found to have a fever, children diagnosed with the H7N9 avian influenza patients time the past 10 days. This case, the emergence of the cases of familial aggregation, does not mean that the virus H7N9 has mutated into a human influenza virus continued to spread from person to person.

Chicken originally bred in the patients of the neighborhood has been processed, sheds and also sprinkle lime powder disinfection

For the presence or absence of contact between the children and their father's illness, the existence of the possibility of human-to-human transmission. Zaozhuang City, director of Critical Care Medicine Li Jinyuan to represent and found no evidence of human-to-human transmission, and he pointed out that the prevalence of children with their parent contact will study as a research direction, but one or two patients can not be drawn from person to person conclusions.

Previously, Shanghai, there have been two cases of human infection with the H7N9 avian influenza family of clusters of cases, involving a couple and a father and son. WHO study concluded that the husband and wife and parent-child co-incidence small-scale gathering the onset still can not prove the existence of human-to-human transmission, the key to studying the co-exposure history, may be common exposure to animal or a certain environment.

Feng Zijian, director of the Chinese Center for Disease Control Health Emergency Center also said that the emergence of a small amount of family clusters of cases, does not mean that the H7N9 virus has mutated into a human influenza virus continued to spread from person to person, but does not exclude the presence of limited human-to-human transmission "capability. Currently, the state health department epidemiological and laboratory investigations of all cases trace shows that H7N9 is an avian influenza virus, the main mode of transmission of infection from birds to people.http://www.guancha.cn/society/2013_04_30_141551.shtml

Safety pledge on poultry imports

Candy Chan and Agence France-Presse
Tuesday, April 30, 2013

Mainland health authorities say poultry products shipped to Hong Kong are safe to eat provided they are properly cooked.
The assurance came as two more mainlanders were confirmed as having the deadly H7N9 strain of bird flu, bringing the total number of infections to 126 - including one in Taiwan.
A patient surnamed Chen died in Shanghai after 12 days of medical treatment failed, Xinhua News Agency said yesterday, raising the death toll to 24.
Cases have been reported in 10 mainland provinces, mainly in the eastern provinces, and one in Taiwan.
The World Health Organization said there has been no evidence so far of human-to-human transmission but warned that H7N9 is "one of the most lethal" influenza viruses ever seen.
Chinese researchers, reporting in The Lancet medical journal, said they have confirmed poultry as a source of the virus among humans.
The General Administration of Quality Supervision, Inspection and Quarantine has declared that mainland poultry exported to Hong Kong is safe for consumption after the virus was detected in Dongguan, Guangdong province, for the first time on Sunday.
About 23,000 samples from 347,000 poultry imported by Hong Kong and Macau were analyzed in the first 23 days of the month, and none tested positive for H7N9.
Authorities over the border have stepped up the monitoring of poultry farms that provide chickens to Hong Kong.
Temperature checks will also be increased as thousands of mainlanders are expected to visit the territory during the May 1 Golden Week holiday.
The central government has ordered the culling of chickens in some areas and the safe disposal of carcasses to prevent the birds from entering the food chain.
Secretary for Food and Health Ko Wing-man said Hong Kong does not intend to stop importing poultry from the mainland since there are no farms that supply the territory within a 13-kilometer perimeter of the affected market in Dongguan.
New cases of H7N9 include those of an 80-year-old farmer from Fujian who was in a serious condition and a four- year-old boy in Shandong. http://www.thestandard.com.hk/news_detail.asp?we_cat=4&art_id=133302&sid=39586284&con_type=1&d_str=20130430&fc=2

Informed that the H7N9 epidemic risk is primarily attributable to the live bird markets

Beijing, April 29 (Reporter Gao Yun-cai) 29, the joint study group, the Department of Agriculture and the World Organization for Animal Health (OIE) informed the H7N9 outbreak investigated the case.Expedition expert, chief expert of the OIE animal disease prevention and control, Dr. Hamilton pointed out that the breeding farms is not detected Up to now, the H7N9 influenza virus infection of poultry farms is very low risk of human infection with the H7N9 risk from the live poultry market environment. http://www.chinanews.com/gn/2013/04-30/4777241.shtml

　According to Xinhua News Agency, Beijing, April 29 (Reporter Dong Jun) - By the Ministry of Agriculture and the World Organization for Animal Health (OIE), a consortium of Expedition 29, said the consumption of cooked poultry and poultry products suitable for processing and cooking is safe, and There is no evidence that human consumption of poultry meat or eggs will be infected with avian influenza virus. http://www.bjd.com.cn/jryw/201304/30/t20130430_3741658.html

Border checks widen as avian ‘flu spreads south

Stephanie Lai | 29/04/2013

 Health Bureau and tourism sector in full-alert as H7N9 bird ‘flu reaches southern China

Thermal infrared detectors will begin operating this morning in all of Macau’s border crossings, the Health Bureau announced, as the first case of H7N9 bird ‘flu was detected in Fujian province.
So far there has been no confirmed case of H7N9 infection in the territory. The bureau said two suspected cases turned out to be negative.
Up to yesterday mainland China had registered 122 people infected with the H7N9 virus, 24 of which died. On Wednesday Taiwan also reported the first avian ‘flu infection case.
Chinese Premier Li Keqiang called on health officials and residents to remain vigilant against the bird ‘flu, as the number of infections rose over the weekend.
“We need to stay on high alert as this is a new virus, and we don’t have all the information,” Mr Li said yesterday during a visit to the mainland’s disease control agency in Beijing, according to a report posted on China National Radio’s website.
Over the weekend Jiangxi, Fujian and Hunan provinces have each reported their first case of the avian ‘flu.
Fujian is Macau’s second-largest visitor market in the mainland, accounting for 177,434 tourists in the first quarter.
Yesterday a chicken was found to be infected with a virus of the H7 strain in a Dongguan poultry wholesale market, Guangdong province, after a spot-check session.
The market was immediately ordered to suspend business and conduct a full-scale sanitisation.
Civic and Municipal Affairs Bureau told Business Daily that it is closely checking the Dongguan case at the moment, even though Macau imports no poultry from the city.
Authorities are still trying to confirm if the chicken was infected with the H7N9 subtype, in what could be the first such case in neighbouring Guangdong province.

Soft impact

The city is expecting a larger flow of mainland tourists starting today as China enters the three-day May 1 vacation.
“For sure we will reinforce the cleaning and sanitising work inside hotels,” Chan Chi Kit, president of Macau Hoteliers & Innkeepers Association, told Business Daily.
“But we are not intending to set fever screening at hotel lobbies because immigration checkpoints are already doing it,” Mr Chan added.
“To add one extra fever sensor at the lobby would make visitors feel too tense.”
The authorities have asked the tourism and hotel sectors to remind visitors to keep good personal hygiene, noted Andy Wu Keng Kuong, president of the Macau Travel Industry Council.
“But it has not gotten to a point where mainland tour groups are giving the tourists sanitising hand gel, which was the case at the time of SARS [severe acute respiratory syndrome outbreak in 2002-2003],” Mr Wu told Business Daily.
Air Macau told Business Daily that it did not notice any impact from the outbreak on its bookings.
But it has affected mainland tour groups, Mr Wu said.
“There will be less tour groups travelling to Hong Kong and Macau during the Labour Day vacation,” he predicted.
The May 1 holidays is “the weakest golden week in the year,” says Mr Wu, mainly because it is shorter than the Lunar New Year or the National Day holidays.
Hotel room rates for the Labour Day vacation will be similar to a regular weekend rate, Mr Wu and Mr Chan said.
“Our occupancy has been doing pretty well in the previous weeks,” said Mr Chan. http://www.macaubusinessdaily.com/Society/Border-checks-widen-avian-%E2%80%98flu-spreads-south

Shandong H7N9 patients with sub-infection, experts say

2013 04 30, 04:27 

....After 20 days of treatment, we are still in the sputum of patients with lower respiratory tract fluid, positive detection of the H7N9 virus. Upper respiratory tract but he was soon no longer be detected viruses.

　　- Chinese Academy of Engineering Li Lanjuan

　　A latest research shows that H7N9 virus more susceptible to attack the lower respiratory tract, nose, throat and upper respiratory tract there is a time and a lower detection rate of

　　Beijing News News According to the website of the Health Department of Shandong Bulletin, the date of Shandong Province new case of human infection of H7N9 avian influenza confirmed cases: children Zhang, male, 4 years old, live in Zaozhuang City Central, whose father was the Shandong The province's first case of human infection with the H7N9 avian influenza confirmed cases. Up to now, Shandong Province reported a total of human infection with the H7N9 avian influenza confirmed cases of two cases. As of yesterday, 17, has been diagnosed 126 people, 24 people were killed, 14 were cured.

　　"At present, only from the point of view of clinical symptoms, father and son performance difference is obvious on avian flu 'person to person' there is no clear evidence to support." The provincial medical treatment team leader, Shandong Chest Hospital Dean high Professor Okawa, 29, said.

　　Children with the disease is still stable

　　According to the briefing, the 27 children with fever symptoms, 28 provincial-level expert group according to the results of laboratory tests and clinical manifestations and epidemiological investigation, the overall judgment that the human infection in children with confirmed cases of the H7N9 avian influenza. Currently, children with the disease is still stable, Zaozhuang City, a hospital for treatment. According to the initial findings and conclusion of the study at home and abroad, has not yet found evidence of infection.

　　Tall Chuan said, "The children are infected pediatric emergency room for treatment, children with the disease in stable condition, eating and sleeping is relatively normal, showing the local symptoms of pneumonia, but her condition is not severe but not critically ill, according to the incidence of and six hours after the beginning of the comparative diagnosis, the development of the children's condition and did not show the rapid deterioration trend. "

　　But the development of children with father's condition is unstable, on admission, no obvious pathological symptoms, but the hospital after 4 hours, the rapid development of the disease, the rate of deterioration soon. "Tall Chuan said the children's father after 7 days after emergency treatment, although not completely out of danger, but relatively stable vital signs.

　　Does not have the performance of human-to-human transmission

　　Tall Chuan, because the presence of a history of close contact, not directly related to exclude possible, but only from the point of view of symptoms, the gap between the two is obvious. The same time, on a time basis, the degree of association of the symptoms of the father and son do not have the "human-to-human transmission performance.

　　H7N9 avian influenza longest incubation period of seven days, the children in father hospitalized for 8 days, was found to have a fever, children diagnosed with the H7N9 avian influenza patients time the past 10 days. This case, the emergence of the cases of familial aggregation, does not mean that the virus H7N9 has mutated into a human influenza virus continued to spread from person to person. Currently, the state health department epidemiological investigation and laboratory tracking of all cases, it is still the main mode of transmission of infection from birds to people.... http://news.sina.com.cn/c/2013-04-30/042726989742.shtml

Epidemiological and risk analysis of the H7N9 subtype influenza outbreak in China at its early stage

ZHUANG QingYe 1†, WANG SuChun 1,2†, WU MeiLi 1,2†, LIU Shuo 1, JIANG WenMing 1, HOU GuangYu 1, LI JinPing 1, WANG KaiCheng 1, YU JianMin1, CHEN JiMing 1* & CHEN JiWang 3

1) China National Avian Influenza Professional Laboratory, China Animal Health and Epidemiology Center, Qingdao 266032, China; 2) China National Avian Influenza Professional Laboratory, China Animal Health and Epidemiology Center, Qingdao 266032, China; 3) The Institute for Personalized Respiratory Medicine, University of Illinois at Chicago, IL 60612, USA

Received April 11, 2013; accepted April 23, 2013


Dozens of human cases infected with H7N9 subtype avian influenza virus (AIV) have been confirmed in China since March, 2013. Distribution data of sexes, ages, professions and regions of the cases were analyzed in this report. The results showed that the elderly cases, especially the male elderly, were significantly more than expected, which is different from human cases of H5N1 avian influenza and human cases of the pandemic H1N1 influenza. 

The outbreak was rated as a Grade III (severe) outbreak, and it would evolve into a Grade IV (very severe) outbreak soon, using a method reported previously. The H7N9 AIV will probably circulate in humans, birds and pigs for years. Moreover, with the driving force of natural selection, the virus will probably evolve into highly pathogenic AIV in birds, and into a deadly pandemic influenza virus in humans. 

Therefore, the H7N9 outbreak has been assumed severe, and it is likely to become very or extremely severe in the future, highlighting the emergent need of forceful scientific measures to eliminate any infected animal flocks. We also described two possible mild scenarios of the future evolution of the outbreak.
hattip Giuseppe Michieli at Flutrackers

http://link.springer.com/content/pdf/10.1007%2Fs11434-013-5880-5.pdf

Clues in H7N9 Influenza Genetic Sequences

April 29, 2013

Researchers quickly evaluated the genetic sequences of the novel H7N9 avian influenza virus that’s caused illness and death in China in recent weeks. The analysis provides clues to the virus’s origin, transmissibility and potential sensitivity to existing treatments.

Transmission electron micrograph of the new influenza A (H7N9) virus.Courtesy of Cynthia S. Goldsmith and Thomas Rowe, Centers for Disease Control and Prevention.

Influenza, or flu, claims thousands of lives nationwide each year. Health experts have been particularly concerned about the threat posed by avian flu viruses. Influenza viruses constantly change, or mutate. Flu pandemics can arise when novel avian strains acquire 2 abilities—to infect humans and to spread easily between people. That’s why health experts keep a close watch on novel viruses.

On March 31, 2013, the Chinese Center for Disease Control and Prevention (Chinese CDC) reported the first cases associated with the H7N9 influenza virus. As of April 21, 2013, 104 human infections had been confirmed, with 21 deaths. To date, the outbreak has been limited to eastern China, and there’s been no evidence of transmission between people.

A team of researchers set out to analyze the novel virus. They were led by Dr. Masato Tashiro of the National Institute of Infectious Diseases in Japan and Dr. Yoshihiro Kawaoka of the University of Wisconsin-Madison and the University of Tokyo. The team studied the genetic sequences of viruses isolated from 4 of the earliest fatal cases. Sequences were provided by the Chinese CDC. The analysis was funded by NIH’s National Institute of Allergy and Infectious Diseases (NIAID) and Japanese organizations. Results appeared on April 11, 2013, in Eurosurveillance.

Influenza virus strains are classified and named based on the viral surface proteins hemagglutinin (HA) and neuraminidase (NA). The combination of H7 HA and N9 NA has previously been seen only in birds. The scientists concluded that the novel strain likely got its surface protein genes from the H7N3 and H11N9 avian influenza strains. Other genes came from H9N2 influenza viruses recently circulating in poultry in China.

While H7N9 causes mild disease in birds, the analysis revealed mutations that may allow it to more efficiently cause disease in mammals. The HA sequences have mutations that have been shown to improve the virus’s ability to bind to human cells. The sequences also contain mutations associated with improved virus reproduction within human cells and with more severe disease in mammals.

The researchers found that the novel H7N9 viruses are likely to be treatable using NA inhibitors, a class of anti-influenza drugs that includes oseltamivir (Tamiflu) and zanamivir (Relenza). However, the novel strain won’t likely be treatable with ion channel inhibitors, another major class of anti-influenza drugs.

“The H7N9 influenza virus is a new concern that the public health and scientific communities will continue to track closely, including watching for any genetic mutations that might enable the virus to become transmissible from person to person or to cause more severe disease,” says NIAID Director Dr. Anthony Fauci. “Having rapid access to the viral genetic information is essential to understanding how the virus is evolving and ultimately to developing a candidate vaccine, if warranted.” 

http://www.nih.gov/researchmatters/april2013/04292013H7N9.htm?utm_source=twitterfeed&utm_medium=twitter#.UX6sFMdtgOU.twitter

Bird flu reappears in Jhapa

RSS BHADRAPUR, April 29: Bird flu has been confirmed in two poultry farms in Jhapa district. With this, 13 cases of bird flu have been detected in various parts of Jhapa district in the last two months.  The District Livestock Office, Bhadrapur, said that cases of the bird flu were confirmed in the chicken reared by Raju Bhudhathoki of Prithvinagar-5 and Subhash Khadka of Chandragadhi. A rapid response team culled 1,270 chicken from the poultry farm of Budhathoki while 151 chickens was destroyed from the poultry farm of Khadka, said Acting Chief of the Office Jagdish Pandey
Published on 2013-04-29 20:39:56 http://www.myrepublica.com/portal/index.php?action=news_details&news_id=53925

Dongguan Dongcheng three birds wholesale market poultry culling of nearly 90,000

http://www.dayoo.com/ Source: Nanfang Daily　 Reviews ( 0 )

Nanfang Daily News (Duan L) - Dongguan City Bureau of Agriculture informed that 19:00 to 2:00 today, Dongcheng three birds wholesale market poultry have been culled and harmless treatment 89864, harmless treatment of 15,387 kg of feed and eggs the market inside and outside the pig bed market environment and for culling operations supplies, appliances, vehicles thoroughly cleaned and disinfected. 27, detected by the provincial animal disease prevention and control center, the initial diagnosis Dongcheng three birds wholesale market a chicken samples for of suspected H7 subtype avian influenza virus infection positive. 28, Dongguan City Animal Health Authority transporting emergency supplies of gloves, protective clothing, sealed bags, medications, disease prevention, guidance and supervision throughout the culling and safe disposal work. Action from the end of the 28th afternoon at 2:00 on the 29th, 383 people were deployed in agriculture, public security and other emergency staff. Had been clear, Dongguan clear provincial and municipal standards and the principles of high compensation standards, including geese 15 yuan / only for poultry and 10 yuan http://news.dayoo.com/society/57401/201304/29/57401_110021989.htm

Taiwanese businessmen may have been infected playing golf

News of the H7N9 avian influenza: H7N9 patients suspected to play ball inadvertently contaminated with bird droppings and infection

0

Source: People's Daily  : Liu Dongmei 2013-04-29 22:21:37

See moreH7N9 avian influenza NewsThe, download Flush customers end

　　According to Taiwan's TVBS television reported, the 53-year-old businessman, suspected H7N9 infection picking up the ball to play golf, inadvertent inadvertently guano contamination ball with H7N9 virus infection.

　　The route of infection of H7N9 First confirmed case in Taiwan, it was revealed that this 53-year-old Taiwanese businessmen to return to Taiwan Although there is no contact with poultry record, but went to the mainland golf course, evaluated by the Disease Control Unit, the Taiwanese may be in the process of picking up the ball in play golf, inadvertently guano contamination golf of H7N9 virus, who were infected.http://field.10jqka.com.cn/20130429/c534356549.shtml